A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles

M. I D Mardjan (1) , S. Périé (1) , J-L Parrain (1) , Laurent Commeiras (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

A versatile copper(I)-catalyzed cascade multicomponent reaction strategy between readily available (Z)-3-iodoacrylic acids, terminal alkynes, and primary amines is reported, leading to a great diversity of complex heterocyclic backbones based on biorelevant indole/lactam scaffolds.

Domaines: Chimie organique

M. I D Mardjan, S. Périé, J-L Parrain, Laurent Commeiras. A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles. Organic & Biomolecular Chemistry, 2017, 15 (15), pp.3304 - 3309. ⟨10.1039/c7ob00532f⟩. ⟨hal-01907698⟩