Skip to Main content Skip to Navigation
Journal articles

Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo

Abstract : Alcohol consumption during pregnancy causes fetal alcohol spectrum disorder, which includes neuroapoptosis and neurobehavioral deficits. The neuroapoptotic effects of alcohol have been hypothesized to involve suppression of brain activity. However, in vitro studies suggest that ethanol acts as a potent stimulant of cortical activity. We explored the effects of alcohol (1-6 g/kg) on electrical activity in the rat somatosensory cortex in vivo at postnatal days P1-23 and compared them with its apoptotic actions. At P4-7, when the peak of alcohol-induced apoptosis was observed, alcohol strongly suppressed spontaneous gamma and spindle-bursts and almost completely silenced neurons in a dose-dependent manner. The dose-dependence of suppression of neuronal activity strongly correlated with the alcohol-induced neuroapoptosis. Alcohol also profoundly inhibited sensory-evoked bursts and suppressed motor activity, a physiological trigger of cortical activity bursts in newborns. The suppressive effects of ethanol on neuronal activity waned during the second and third postnatal weeks, when instead of silencing the cortex, alcohol evoked delta-wave electrographic activity. Thus, the effects of alcohol on brain activity are strongly age-dependent, and during the first postnatal week alcohol profoundly inhibits brain activity. Our findings suggest that the adverse effects of alcohol in the developing brain involve suppression of neuronal activity.
Document type :
Journal articles
Complete list of metadatas

Cited literature [69 references]  Display  Hide  Download

https://hal-amu.archives-ouvertes.fr/hal-01962304
Contributor : Fanny Pra <>
Submitted on : Thursday, December 20, 2018 - 3:12:29 PM
Last modification on : Friday, October 23, 2020 - 4:35:45 PM
Long-term archiving on: : Friday, March 22, 2019 - 1:07:27 PM

File

Lebedeva_Cer_Cortex 2017.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Julia Lebedeva, Andrei Zakharov, Elena Ogievetsky, Alina Minlebaeva, Elena Gerasimova, et al.. Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo. Cerebral Cortex, Oxford University Press (OUP), 2015, pp.bhv293. ⟨10.1093/cercor/bhv293⟩. ⟨hal-01962304⟩

Share

Metrics

Record views

133

Files downloads

262