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CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY AND MALIGNANCY: A SYSTEMATIC REVIEW

Abstract : A systematic review of the literature was performed on the association of chronic inflammatory demyelinating polyneuropathy (CIDP) with malignancy. Hematological disorders are the most common association, particulalry non-Hodgkin lymphoma. CIDP frequently precedes the malignancy diagnosis, and there is a favorable CIDP response to treatment more than 70% of the time. Melanoma is the second most common association and may be accompanied by antiganglioside antibodies; CIDP shows a good response to immunotherapy. Other cancers are rare, with variable timings and presentations but good responses to immunomodulation and/or cancer therapy. Unusual neurological features such as ataxia, distal/upper limb predominance, or cranial/respiratory/autonomic involvement may suggest associated malignancy as may abdominal pain, diarrhea/constipation, poor appetite/weight loss, dermatological lesions, and lymphadenopathy. In the appropriate clinical and electrophysiological setting, CIDP associated with cancer should be considered. Immunomodulatory therapy, cancer treatment alone, or a combination may be effective.
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https://hal-amu.archives-ouvertes.fr/hal-02000321
Contributor : Valérie Gall <>
Submitted on : Wednesday, January 30, 2019 - 3:11:29 PM
Last modification on : Thursday, February 7, 2019 - 5:04:53 PM

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Yusuf A. Rajabally, Shahram Attarian. CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY AND MALIGNANCY: A SYSTEMATIC REVIEW. Muscle & Nerve, 2018, 57 (6), pp.875-883. ⟨hal-02000321⟩

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