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DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US?

Marc Benderitter 1 Thierry Pourcher 2 Jean-Charles Martin 3 Jacques Darcourt 2, 4, 5 Pierre Guigon 6 Francois Caire-Maurisier Annick Pech Dalila Lebsir Clement Rosique Julien Guglielmi 2 Francois Rebiere 7 Karine Tack 8 Guillaume Phan 9 Philippe Lestaevel 10 Maamar Souidi 11 Jean-Rene Jourdain
1 PRP-HOM/SRBE/LRTE
2 TIRO-MATOs - UMR E4320 - Transporteurs et Imagerie, Radiothérapie en Oncologie et Mécanismes biologiques des Altérations du Tissu Osseux
TIRO-MATOs - UMR E4320 : UMR E4320, SHFJ - Service Hospitalier Frédéric Joliot
3 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
4 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]
5 COMUE UCA - COMUE Université Côte d'Azur (2015-2019)
6 UTC - Université de Technologie de Compiègne
7 Institut de RadioProtection et de Sureté Nucléaire, Direction de la Radioprotection de l’Homme
8 IRSN - Institut de Radioprotection et de Sûreté Nucléaire
9 Université de Lille, Sciences Humaines et Sociales
10 Institut de Radioprotection et de Sûreté Nucléaire
11 Laboratoire de RadioToxicologie Expérimentale
Abstract : Single dose of potassium iodide (KI) is recommended to prevent the risk of thyroid cancer during nuclear accidents. However in the case of repeated/protracted radioiodine release, a unique dose of KI may not protect efficiently the thyroid against the risk of further developing a radiation-induced cancer. The new WHO guidelines for the use in planning for and responding to radiological and nuclear emergencies identify the need of more data on this subject as one of the four research priorities. The aims of the PRIODAC project are (1) to assess the associated side effects of repeated intakes of KI, (2) to better understand the molecular mechanisms regulating the metabolism of iodine, (3) to revise the regulatory French marketing authorization of 65-mg KI tablets and (4) to develop new recommendations related to the administration of KI toward a better international harmonization. A review of the literature and the preliminary data are presented here.
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https://hal-amu.archives-ouvertes.fr/hal-02067478
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Submitted on : Thursday, March 14, 2019 - 11:42:08 AM
Last modification on : Monday, December 13, 2021 - 9:15:01 AM

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UNIV-AMU | UNIV-COMPIEGNE | INRA | IRSN | CEA | UNIV-LILLE3 | UNIV-COTEDAZUR | CEA-DRF | BIAM | CEA-CAD | CEA-UPSAY | JOLIOT | SHFJ | UNIV-PARIS-SACLAY | INRAE | GS-ENGINEERING

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Marc Benderitter, Thierry Pourcher, Jean-Charles Martin, Jacques Darcourt, Pierre Guigon, et al.. DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US?. RADIATION PROTECTION DOSIMETRY, 2018, 182 (1), pp.67-79. ⟨10.1093/rpd/ncy129⟩. ⟨hal-02067478⟩

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