DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US?

Marc Benderitter; Thierry Pourcher; Jean-Charles Martin; Jacques Darcourt; Pierre Guigon; Francois Caire-Maurisier; Annick Pech; Dalila Lebsir; Clement Rosique; Julien Guglielmi; Francois Rebiere; Karine Tack; Guillaume Phan; Philippe Lestaevel; Maamar Souidi; Jean-Rene Jourdain

doi:10.1093/rpd/ncy129

Journal articles

DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US?

Marc Benderitter ¹ Thierry Pourcher ² Jean-Charles Martin ³ Jacques Darcourt ^{2, 4, 5} Pierre Guigon ⁶ Francois Caire-Maurisier Annick Pech Dalila Lebsir Clement Rosique Julien Guglielmi ² Francois Rebiere ⁷ Karine Tack ⁸ Guillaume Phan ⁹ Philippe Lestaevel ¹⁰ Maamar Souidi ¹¹ Jean-Rene Jourdain

1 PRP-HOM/SRBE/LRTE

2 TIRO - UMR E4320 - Transporteurs en Imagerie et Radiothérapie en Oncologie

SHFJ - Service Hospitalier Frédéric Joliot, TIRO-MATOs - UMR E4320 : UMR E4320

3 C2VN - Centre recherche en CardioVasculaire et Nutrition

4 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]

5 COMUE UCA - COMUE Université Côte d'Azur (2015 - 2019)

6 UTC - Université de Technologie de Compiègne

7 Institut de RadioProtection et de Sureté Nucléaire, Direction de la Radioprotection de l’Homme

8 IRSN - Institut de Radioprotection et de Sûreté Nucléaire

9 Université de Lille, Sciences Humaines et Sociales

10 Institut de Radioprotection et de Sûreté Nucléaire

11 Laboratoire de RadioToxicologie Expérimentale

Abstract : Single dose of potassium iodide (KI) is recommended to prevent the risk of thyroid cancer during nuclear accidents. However in the case of repeated/protracted radioiodine release, a unique dose of KI may not protect efficiently the thyroid against the risk of further developing a radiation-induced cancer. The new WHO guidelines for the use in planning for and responding to radiological and nuclear emergencies identify the need of more data on this subject as one of the four research priorities. The aims of the PRIODAC project are (1) to assess the associated side effects of repeated intakes of KI, (2) to better understand the molecular mechanisms regulating the metabolism of iodine, (3) to revise the regulatory French marketing authorization of 65-mg KI tablets and (4) to develop new recommendations related to the administration of KI toward a better international harmonization. A review of the literature and the preliminary data are presented here.

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Journal articles

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Life Sciences [q-bio]

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https://hal-amu.archives-ouvertes.fr/hal-02067478
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Submitted on : Thursday, March 14, 2019 - 11:42:08 AM
Last modification on : Tuesday, October 13, 2020 - 3:10:53 AM

DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US?

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DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US?

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