DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US? - Archive ouverte HAL Access content directly
Journal Articles RADIATION PROTECTION DOSIMETRY Year : 2018

DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US?

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Francois Caire-Maurisier
  • Function : Author
Annick Pech
  • Function : Author
Dalila Lebsir
  • Function : Author
Clement Rosique
  • Function : Author
Jean-Rene Jourdain
  • Function : Author

Abstract

Single dose of potassium iodide (KI) is recommended to prevent the risk of thyroid cancer during nuclear accidents. However in the case of repeated/protracted radioiodine release, a unique dose of KI may not protect efficiently the thyroid against the risk of further developing a radiation-induced cancer. The new WHO guidelines for the use in planning for and responding to radiological and nuclear emergencies identify the need of more data on this subject as one of the four research priorities. The aims of the PRIODAC project are (1) to assess the associated side effects of repeated intakes of KI, (2) to better understand the molecular mechanisms regulating the metabolism of iodine, (3) to revise the regulatory French marketing authorization of 65-mg KI tablets and (4) to develop new recommendations related to the administration of KI toward a better international harmonization. A review of the literature and the preliminary data are presented here.
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Dates and versions

hal-02067478 , version 1 (14-03-2019)

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Marc Benderitter, Thierry Pourcher, Jean-Charles Martin, Jacques Darcourt, Pierre Guigon, et al.. DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US?. RADIATION PROTECTION DOSIMETRY, 2018, 182 (1), pp.67-79. ⟨10.1093/rpd/ncy129⟩. ⟨hal-02067478⟩
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