Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

Jessica Perego; Andreia Mendes; Clarisse Bourbon; Voahirana Camosseto; Alexis Combes; Hong Liu; Thien-Phong Vu Manh; Alexandre Dalet; Lionel Chasson; Lionel Spinelli; Nathalie Bardin; Laurent Chiche; Manuel Santos; Evelina Gatti; Philippe Pierre

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Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

Jessica Perego ¹ Andreia Mendes ¹ Clarisse Bourbon ¹ Voahirana Camosseto ¹ Alexis Combes ¹ Hong Liu Thien-Phong Vu Manh ¹ Alexandre Dalet ¹ Lionel Chasson ¹ Lionel Spinelli ¹ Nathalie Bardin ^{2, 3, 4} Laurent Chiche ⁵ Manuel Santos ⁶ Evelina Gatti ¹ Philippe Pierre ¹

1 CIML - Centre d'Immunologie de Marseille - Luminy

2 VRCM - Vascular research center of Marseille

3 Laboratoire d'Immunologie [Hôpital de la Conception - APHM]

4 C2VN - Centre recherche en CardioVasculaire et Nutrition

5 Hôpital Européen [Fondation Ambroise Paré - Marseille]

6 iBiMED - Institute for Research in Biomedicine

Jessica Perego ¹ AuthorId : 1497769
Author

Andreia Mendes ¹ AuthorId : 1497768
Author

Clarisse Bourbon ¹ AuthorId : 869082
Author

Voahirana Camosseto ¹ AuthorId : 199238
Author

Alexis Combes ¹ AuthorId : 1456753
Author

Hong Liu AuthorId : 905480
Author

Thien-Phong Vu Manh ¹ AuthorId : 695378
Author

Alexandre Dalet ¹ AuthorId : 711333
Author

Lionel Chasson ¹ AuthorId : 199438
Author

Lionel Spinelli ¹ AuthorId : 179510

Author IdHAL : lionel-spinelli ORCID : https://orcid.org/0000-0001-9228-8141

Nathalie Bardin ^{2, 3, 4} AuthorId : 750173
Author

Laurent Chiche ⁵ AuthorId : 408368
Author

Manuel Santos ⁶ AuthorId : 1577891

Author

Evelina Gatti ¹ AuthorId : 199239
Author

Philippe Pierre ¹ AuthorId : 93691
Author

1 CIML - Centre d'Immunologie de Marseille - Luminy (Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09 - France) StructId : 182245

INSERM - Institut National de la Santé et de la Recherche Médicale : UMR_S 1104 (101, rue de Tolbiac, 75013 Paris - France) StructId : 303623
AMU - Aix Marseille Université : UM 2 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France) StructId : 198056
CNRS - Centre National de la Recherche Scientifique : UMR7280 (France) StructId : 441569

2 VRCM - Vascular research center of Marseille (Faculté de Pharmacie, 27 bd Jean Moulin 13385 Marseille Cedex 5 - France) StructId : 182181

AMU - Aix Marseille Université : UMR S1076 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France) StructId : 198056
INSERM - Institut National de la Santé et de la Recherche Médicale : U1076 (101, rue de Tolbiac, 75013 Paris - France) StructId : 303623

3 Laboratoire d'Immunologie [Hôpital de la Conception - APHM] (147, boulevard Baille 13385 Marseille cedex 05 - France) StructId : 458410

APHM - Assistance Publique - Hôpitaux de Marseille (Direction générale AP-HM 80, rue Brochier 13 354 Marseille Cedex 5 - France) StructId : 300073
INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France) StructId : 303623
LA CONCEPTION - Hôpital de la Conception [CHU - APHM] (147 Boulevard Baille 13005 Marseille - France) StructId : 417872
CNRS - Centre National de la Recherche Scientifique (France) StructId : 441569

4 C2VN - Centre recherche en CardioVasculaire et Nutrition (Faculté de Pharmacie - Timone 27, boulevard Jean Moulin 13385 Marseille cedex 5 - France) StructId : 527021

INRA - Institut National de la Recherche Agronomique : UMR_S1263 (France) StructId : 92114
AMU - Aix Marseille Université : UMR_S1263 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France) StructId : 198056
INSERM - Institut National de la Santé et de la Recherche Médicale : UMR_S1263 (101, rue de Tolbiac, 75013 Paris - France) StructId : 303623

5 Hôpital Européen [Fondation Ambroise Paré - Marseille] (6 rue Désirée Clary 13003 Marseille - France) StructId : 360866

6 iBiMED - Institute for Research in Biomedicine (University of Aveiro, Aveiro - Portugal) StructId : 486749

Universidade de Aveiro (Campus Universitário de Santiago 3810-193 Aveiro - Portugal) StructId : 60947

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Life Sciences [q-bio] / Cellular Biology

Life Sciences [q-bio] / Immunology

Complete list of metadatas

https://hal-amu.archives-ouvertes.fr/hal-02086881
Contributor : Lionel Spinelli <>
Submitted on : Monday, April 1, 2019 - 4:17:24 PM
Last modification on : Thursday, May 2, 2019 - 2:14:16 PM

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HAL Id : hal-02086881, version 1
DOI : 10.1126/scisignal.aam8104

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UNIV-AMU | CNRS | INRA

Citation

Jessica Perego, Andreia Mendes, Clarisse Bourbon, Voahirana Camosseto, Alexis Combes, et al.. Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex. Science Signaling, American Association for the Advancement of Science, 2018, 11 (514), pp.eaam8104. ⟨10.1126/scisignal.aam8104⟩. ⟨hal-02086881⟩

Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

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Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

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