Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

Jessica Perego (1) , Andreia Mendes (1) , Clarisse Bourbon (1) , Voahirana Camosseto (1) , Alexis Combes (1) , Hong Liu , Thien-Phong Vu Manh (1) , Alexandre Dalet (1) , Lionel Chasson (1) , Lionel Spinelli (1) , Nathalie Bardin (2, 3, 4) , Laurent Chiche (5) , Manuel Santos (6) , Evelina Gatti (1) , Philippe Pierre (1)

1 CIML - Centre d'Immunologie de Marseille - Luminy
2 VRCM - Vascular research center of Marseille
3 Laboratoire d'Immunologie [Hôpital de la Conception - APHM]
4 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
5 Hôpital Européen [Fondation Ambroise Paré - Marseille]
6 iBiMED - Institute for Research in Biomedicine

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Cellular Biology; Life Sciences [q-bio]; Immunology

Jessica Perego, Andreia Mendes, Clarisse Bourbon, Voahirana Camosseto, Alexis Combes, et al.. Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex. Science Signaling, 2018, 11 (514), pp.eaam8104. ⟨10.1126/scisignal.aam8104⟩. ⟨hal-02086881⟩