Lower Pregnancy Rates After IVF in Women Working as Occupational Cleaners A Preliminary Longitudinal Study

Sabrina Soen (1) , Jeanne Perrin (2, 1) , Irène Sari-Minodier (2) , Elisabeth Jouve (3) , Audrey Gnisci (1) , Blandine Courbiere (1, 2)

1 Centre Clinico-Biologique d’Assistance Médicale à la Procréation - CECOS [Hôpital de la Conception - APHM]
2 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
3 CIC - Centre d'Investigation Clinique [Hôpital de la Conception - APHM]

OBJECTIVE: To assess clinical, biological, and environ­ mental factors influencing pregnancy rates (PRs) after in vitro fertilization (IVF), and to study the influence of occupational, lifestyle, and domestic exposure on PR. STUDY DESIGN: A longi­ tudinal cohort study was performed in women who started an IVF cycle with a self­administered question­ naire concerning their envi­ ronmental and occupation­ al exposure. Medical data were obtained from medical files. RESULTS: Among 534 cycles, we showed a variety of factors that had an impact on PR: age, infertility du­ ration, number of mature oocytes and embryos. After multivariate analysis, women with "elementary" occu­ pations had a significantly lower PR (OR 5.6; 95% CI 1.3-23.7). Among them, 82% were cleaners. CONCLUSION: This preliminary result leads us to focus on a socio­professional category that is already rec­ ognized in the literature as at risk for congenital abnor­ malities during pregnancy. Further cohort studies are needed to study the influence of socio­professional cate­ gory on PR.

Keywords: Assisted reproductive technologies; Infertility; In vitro fertilization; IVF; Pregnancy rate; Occupational exposure

Domains: Life Sciences [q-bio]; Reproductive Biology; Sexual reproduction; Life Sciences [q-bio]; Development Biology; Gametogenesis; Life Sciences [q-bio]; Ecology, environment; Health; Life Sciences [q-bio]; Human health and pathology; Gynecology and obstetrics; Environmental Sciences; Environmental and Society

Sabrina Soen, Jeanne Perrin, Irène Sari-Minodier, Elisabeth Jouve, Audrey Gnisci, et al.. Lower Pregnancy Rates After IVF in Women Working as Occupational Cleaners A Preliminary Longitudinal Study. The journal of Reproductive Medicine, 2018. ⟨hal-02091611⟩