Lower Pregnancy Rates After IVF in Women Working as Occupational Cleaners A Preliminary Longitudinal Study
Résumé
OBJECTIVE: To assess clinical, biological, and environ mental factors influencing pregnancy rates (PRs) after in vitro fertilization (IVF), and to study the influence of occupational, lifestyle, and domestic exposure on PR.
STUDY DESIGN: A longi tudinal cohort study was performed in women who started an IVF cycle with a selfadministered question naire concerning their envi ronmental and occupation al exposure. Medical data were obtained from medical files.
RESULTS: Among 534 cycles, we showed a variety of factors that had an impact on PR: age, infertility du ration, number of mature oocytes and embryos. After multivariate analysis, women with "elementary" occu pations had a significantly lower PR (OR 5.6; 95% CI 1.3-23.7). Among them, 82% were cleaners.
CONCLUSION: This preliminary result leads us to focus on a socioprofessional category that is already rec ognized in the literature as at risk for congenital abnor malities during pregnancy. Further cohort studies are needed to study the influence of socioprofessional cate gory on PR.
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