Elaboration of antimicrobial polymeric materials by dispersion of well-defined amphiphilic methacrylic SG1-based copolymers - Archive ouverte HAL Access content directly
Journal Articles Polymer Chemistry Year : 2018

Elaboration of antimicrobial polymeric materials by dispersion of well-defined amphiphilic methacrylic SG1-based copolymers

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Abstract

Bacterial resistance to antibiotics is a major public health problem and there is an urgent need to find new antimicrobial materials to circumvent the development of resistant pathogens. The aim of this work is to propose an efficient and versatile method for the elaboration of antimicrobial polymeric materials based on the simple dispersion of a low amount of high molecular weight (M-n \textgreater 20 000 g mol(-1)) amphiphilic methacrylic copolymers prepared by nitroxide-mediated polymerization in different common organic matrices (here PS and PMMA). More precisely, after studying the influence of different copolymer parameters on their biological activity (the amount and type of comonomer (styrene or acrylonitrile), the architecture (random or diblock), and the type of cationic charge (permanent or not)), some selected candidates were dispersed in PS and PMMA matrices and were shown to efficiently turn these inactive materials into antibacterial ones with out a significant hemolytic character. In particular, only 0.02 wt% of antimicrobial copolymers were sufficient to confer an activity against both Gram positive (B. subtilis) and Gram negative (E. coli) bacteria.
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Dates and versions

hal-02091857 , version 1 (06-04-2019)

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Belkacem Tarek Benkhaled, Slim Hadiouch, Hamza Olleik, Josette Perrier, Cédric Ysacco, et al.. Elaboration of antimicrobial polymeric materials by dispersion of well-defined amphiphilic methacrylic SG1-based copolymers. Polymer Chemistry, 2018, 9 (22), pp.3127--3141. ⟨10.1039/c8py00523k⟩. ⟨hal-02091857⟩
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