Claramines: A New Class Of Broad-Spectrum Antimicrobial Agents With Bimodal Activity

Marine Blanchet (1) , Diane Borselli (2, 3) , Anne Rodallec (4) , Franck Peiretti (5) , Nicolas Vidal (6) , Jean-Michel M Bolla (2, 3) , Carole Digiorgio (7) , Kelly R Morrison (8) , William M Wuest (8) , Jean Michel Brunel (1)

1 CRCM - Centre de Recherche en Cancérologie de Marseille
2 MCT - Membranes et cibles thérapeutiques
3 IRBA - Institut de Recherche Biomédicale des Armées [Antenne Marseille]
4 SMARTc - Simulation and Modeling of Adaptive Response for Therapeutics in Cancer
5 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
6 ICR - Institut de Chimie Radicalaire
7 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
8 Emory University [Atlanta, GA]

The emergence of multidrug resistant bacteria/pathogens has highlighted the need for the development of new antibiotics. In this manuscript, we report herein our results dealing with the broad spectrum of antibacterial activity against both sensitive and resistant Gram-negative and Gram-positive bacterial strains of an easily prepared water soluble polyaminosterol compound namely claramine A1. We will also demonstrate its peculiar mechanism of action (different from all the well-known classes of antibiotics) towards Gram-negative and Gram-positive bacteria. Finally, due to its low cytotoxicity, this class of molecules could constitute an effective response to combat the emergence of multidrug resistant bacteria and nosocomial diseases.

Keywords: Polyamine derivative; Antibacterial agents; Steroids; Antibiotics; Bile acid

Domains: Chemical Sciences; Life Sciences [q-bio]; Life Sciences [q-bio]; Microbiology and Parasitology

Marine Blanchet, Diane Borselli, Anne Rodallec, Franck Peiretti, Nicolas Vidal, et al.. Claramines: A New Class Of Broad-Spectrum Antimicrobial Agents With Bimodal Activity. ChemMedChem, 2018, 13 (10), pp.1018-1027. ⟨10.1002/cmdc.201800073⟩. ⟨hal-02110834⟩