Skip to Main content Skip to Navigation
Journal articles

Design, synthesis, activity evaluation and QSAR studies of novel antimalarial 1,2,3-triazolo-beta-lactam derivatives

Abstract : This paper describes the synthesis of some new beta-lactam derivatives containing the 1,2,3-triazole moiety. All the compounds were evaluated for their in vitro antimicrobial and antimalarial activities. Moderate to excellent antimalarial activities were encountered. The results showed that compounds 5a, 5c, 5f, 5i exhibited the most potent antimalarial activity with IC50 values of 0.85, < 0.97, < 0.97, 1.81 mu M against chloroquine-resistant P. falciparum K1 strain. A QSAR study highlights the structure-activity relationships that correlate the observed antimalarial activities with changes in the compounds' structural features.
Document type :
Journal articles
Complete list of metadatas

https://hal-amu.archives-ouvertes.fr/hal-02143574
Contributor : Ghislain Bidaut <>
Submitted on : Wednesday, May 29, 2019 - 2:48:32 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:17 PM

Identifiers

Collections

Citation

Aliasghar Jarrahpour, Malihe Aye, Javad Ameri Rad, Saeed Yousefinejad, Veronique Sinou, et al.. Design, synthesis, activity evaluation and QSAR studies of novel antimalarial 1,2,3-triazolo-beta-lactam derivatives. Journal- Iranian Chemical Society, Iranian Chemical Society, 2018, 15 (6), pp.1311-1326. ⟨10.1007/s13738-018-1330-2⟩. ⟨hal-02143574⟩

Share

Metrics

Record views

74