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Phospholipase D and phosphatidic acid in the biogenesis and cargo loading of extracellular vesicles

Abstract : Extracellular vesicles released by viable cells (exosomes and microvesicles) have emerged as important organelles supporting cell-cell communication. Because of their potential therapeutic significance, important efforts are being made toward characterizing the contents of these vesicles and the mechanisms that govern their biogenesis. It has been recently demonstrated that the lipid modifying enzyme, phospholipase D (PLD)2, is involved in exosome production and acts downstream of the small GTPase, ARF6. This review aims to recapitulate our current knowledge of the role of PLD2 and its product, phosphatidic acid, in the biogenesis of exosomes and to propose hypotheses for further investigation of a possible central role of these molecules in the biology of these organelles.
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https://hal-amu.archives-ouvertes.fr/hal-02143653
Contributor : Ghislain Bidaut <>
Submitted on : Wednesday, May 29, 2019 - 2:52:14 PM
Last modification on : Thursday, May 30, 2019 - 1:38:54 AM

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Antonio Luis Egea-Jimenez, Pascale Zimmermann. Phospholipase D and phosphatidic acid in the biogenesis and cargo loading of extracellular vesicles. Journal of Lipid Research, 2018, 59 (9), pp.1554-1560. ⟨10.1194/jlr.R083964⟩. ⟨hal-02143653⟩

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