Skip to Main content Skip to Navigation
Journal articles

Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T

Abstract : T1 mapping lacks specificity toward a single particular biological feature, however it has the potential to discriminate spinal cord regional tissue organization and characterize tissue microstructural impairments occurring in neurodegenerative pathologies. In this exploratory work, T1 mapping of the cervical spinal cord with a 300-μm in-plane resolution was performed on fourteen healthy subjects at 7T, using the MP2RAGE sequence. Individual images from C1 to C7 vertebral levels provided a clear delineation of spinal cord anatomical details and substructures including motor columns within gray matter (GM) horns, anterior median fissure, central canal, ventral, lateral and dorsal white matter (WM) fasciculi, and posterior median septum. Group studies highlighted regional T1 differences between regions of interest so far hardly visible at lower spatial resolution. Two-dimensional averaged T1 maps and manual parcellation of GM and WM substructures were built based on these data. Benefiting from the very high spatial resolution achievable at ultra-high field for T1 mapping, this work contributes to improve the in vivo characterization of the cervical spinal cord. By allowing investigation within a wider range of functional regions, it also opens new perspectives for pathology diagnosis such as motor neuron disease, neuropathic pain or refined investigation of neurodegeneration.
Document type :
Journal articles
Complete list of metadatas

Cited literature [51 references]  Display  Hide  Download

https://hal-amu.archives-ouvertes.fr/hal-02370673
Contributor : Virginie Callot <>
Submitted on : Thursday, February 20, 2020 - 9:24:23 AM
Last modification on : Wednesday, August 19, 2020 - 12:08:26 PM
Long-term archiving on: : Thursday, May 21, 2020 - 1:15:02 PM

Files

Manuscript_R1_NeuroImage2020.p...
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Collections

Citation

Aurélien Massire, Henitsoa Rasoanandrianina, Maxime Guye, Virginie Callot. Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T. NeuroImage, Elsevier, 2020, 205, pp.116275. ⟨10.1016/j.neuroimage.2019.116275⟩. ⟨hal-02370673⟩

Share

Metrics

Record views

97

Files downloads

63