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Journal Pre-proof Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors

Abstract : Cannabis usage is increasing with its widespread legalization. Cannabis use by mothers during lactation transfers active cannabinoids to the developing offspring during this critical period and alters postnatal neurodevelopment. A key neurodevelopmental landmark is the excitatory to inhibitory gamma-aminobutyric acid (GABA) switch caused by reciprocal changes in expression ratios of the K+/Cl− transporters potassium-chloride cotransporter 2 (KCC2) and sodium-potassium-chloride transporter (NKCC1).
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https://hal-amu.archives-ouvertes.fr/hal-02389004
Contributor : Christophe Pellegrino <>
Submitted on : Monday, December 2, 2019 - 11:50:06 AM
Last modification on : Wednesday, August 19, 2020 - 12:08:23 PM
Long-term archiving on: : Tuesday, March 3, 2020 - 6:37:35 PM

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Andrew Scheyer, Milene Borsoi, Jim Wager-Miller, Anne-Laure Pélissier-Alicot, Michelle Murphy, et al.. Journal Pre-proof Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors. Biological Psychiatry, Elsevier, 2019, ⟨10.1016/j.biopsych.2019.08.023⟩. ⟨hal-02389004⟩

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