Journal Pre-proof Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors

Andrew F Scheyer (1) , Milene Borsoi (1) , Jim Wager-Miller (2) , Anne-Laure Pélissier-Alicot (1, 3, 4) , Michelle N Murphy (2) , Ken Mackie (2) , Olivier Manzoni (1, 2)

1 INMED - INSERM U1249 - Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université]
2 Indiana University [Bloomington]
3 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
4 TIMONE - Hôpital de la Timone [CHU - APHM]

Cannabis usage is increasing with its widespread legalization. Cannabis use by mothers during lactation transfers active cannabinoids to the developing offspring during this critical period and alters postnatal neurodevelopment. A key neurodevelopmental landmark is the excitatory to inhibitory gamma-aminobutyric acid (GABA) switch caused by reciprocal changes in expression ratios of the K+/Cl− transporters potassium-chloride cotransporter 2 (KCC2) and sodium-potassium-chloride transporter (NKCC1).

Keywords: Cannabis; CB1 receptor; GABA; Endocannabinoid; Lactation; Maturation; Perinatal; Prefrontal cortex

Domains: Cognitive science; Neuroscience; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]

Andrew F Scheyer, Milene Borsoi, Jim Wager-Miller, Anne-Laure Pélissier-Alicot, Michelle N Murphy, et al.. Journal Pre-proof Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors. Biological Psychiatry, 2019, ⟨10.1016/j.biopsych.2019.08.023⟩. ⟨hal-02389004⟩