Journal Pre-proof Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors - Archive ouverte HAL Access content directly
Journal Articles Biological Psychiatry Year : 2019

Journal Pre-proof Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors

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Abstract

Cannabis usage is increasing with its widespread legalization. Cannabis use by mothers during lactation transfers active cannabinoids to the developing offspring during this critical period and alters postnatal neurodevelopment. A key neurodevelopmental landmark is the excitatory to inhibitory gamma-aminobutyric acid (GABA) switch caused by reciprocal changes in expression ratios of the K+/Cl− transporters potassium-chloride cotransporter 2 (KCC2) and sodium-potassium-chloride transporter (NKCC1).
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Dates and versions

hal-02389004 , version 1 (02-12-2019)

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Andrew F Scheyer, Milene Borsoi, Jim Wager-Miller, Anne-Laure Pélissier-Alicot, Michelle N Murphy, et al.. Journal Pre-proof Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors. Biological Psychiatry, 2019, ⟨10.1016/j.biopsych.2019.08.023⟩. ⟨hal-02389004⟩
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