HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Book sections

Cardiopharyngeal progenitor specification: multiple roads to the heart and head muscles

Abstract : During embryonic development, the heartarise from various sourcesof undifferentiated mesodermal progenitors, with an additional contribution from ectodermal neural crest cells. Mesodermal cardiac progenitorsareplasticand multipotent,but are nevertheless specified to a precise heart region and cell type very early during development. Recent findings have defined both this lineage plasticity and early commitment of cardiac progenitors, using a combination of single-cell and population analyses. In this review, we discuss several aspects of cardiac progenitor specification. We discuss their markers, fate potential in vitroand in vivo, early segregation and commitment, and also intrinsic and extrinsic cues regulatinglineage restrictionfrom multipotency to a specific cell type of the heart. Finally, we also discuss the sub-divisionsof the cardiopharyngeal field, and the shared origins of the heart with other mesodermal derivatives, including head and neck muscles.
Complete list of metadata

Cited literature [166 references]  Display  Hide  Download

https://hal-amu.archives-ouvertes.fr/hal-02440680
Contributor : Fabienne Lescroart Connect in order to contact the contributor
Submitted on : Wednesday, January 15, 2020 - 12:07:58 PM
Last modification on : Wednesday, November 3, 2021 - 5:49:54 AM
Long-term archiving on: : Thursday, April 16, 2020 - 3:35:16 PM

File

Chapter-Cardiopharyngeal proge...
Files produced by the author(s)

Identifiers

  • HAL Id : hal-02440680, version 1

Collections

Citation

Benjamin Swedlund, Fabienne Lescroart. Cardiopharyngeal progenitor specification: multiple roads to the heart and head muscles. Heart Development and Disease, 2019, 978-1-621823-58-2. ⟨hal-02440680⟩

Share

Metrics

Record views

42

Files downloads

111