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Influence of gender, age, shelf-life, and conservation method on the biomechanical behavior of colon tissue under dynamic solicitation

Résumé : Background: Data from biomechanical tissue sample studies of the human digestive tract are highly variable. The aim of this study was to investigate 4 factors which could modify the mechanical response of human colonic specimens placed under dynamic solicitation until tissue rupture: gender, age, shelf-life and conservation method. Methods: We performed uniaxial dynamic tests of human colonic specimens. Specimens were taken according to three different protocols: refrigerated cadavers without embalming, embalmed cadavers and fresh colonic tissue. A total of 143 specimens were subjected to tensile tests, at a speed of 1ms?1. Findings: Young's modulus of the different conservation protocols are as follows: embalmed, 3.08 ± 1.99; fresh, 2.97 ± 2.59; and refrigerated 3.17 ± 2.05. The type of conservation does not modify the stiffness of the tissue (p=0.26) but does modify the stress necessary for rupture (p < 0.001) and the strain required to obtain lesions of the outer layer and the inner layer (p < 0.001 and p < 0.05, respectively). Gender is also a factor responsible for a change in the mechanical response of the colon. The age of the subjects and the shelf-life of the bodies did not represent factors influencing the mechanical behavior of the colon (p > 0.05). Interpretation: The mechanical response of the colon tissue showed a biphasic injury process depending on gender and method of preservation. The age and shelf-life of anatomical subjects do not alter the mechanical response of the colon.
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Submitted on : Thursday, June 10, 2021 - 11:37:11 AM
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Damien Massalou, Catherine Masson, Sanae Afquir, Patrick Baque, Pierre Jean Arnoux, et al.. Influence of gender, age, shelf-life, and conservation method on the biomechanical behavior of colon tissue under dynamic solicitation. Clinical Biomechanics, Elsevier, 2019, 65, pp.34-40. ⟨10.1016/j.clinbiomech.2019.03.017⟩. ⟨hal-02867999⟩

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