Excito-repellency and biological safety of β-caryophyllene oxide against Aedes albopictus and Anopheles dirus (Diptera: Culicidae)

Jirod Nararak (1, 2) , Carole Di Giorgio (3) , Chutipong Sukkanon (1) , Valerie Mahiou-Leddet (3) , Evelyne Ollivier (3) , Sylvie Manguin (2) , Theeraphap Chareonviriyaphap (1)

1 KU - Kasetsart University
2 HSM - Hydrosciences Montpellier
3 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale

 β-caryophyllene oxide had stronger repellent and irritant effect than DEET  Ae. albopictus was more sensitive to β-caryophyllene oxide than An. dirus while, knockdown responses (37%) were observed in An. dirus exposed to 1% β-caryophyllene oxide in the contact trial.  β-caryophyllene oxide did not show any phototoxic activity.  None of the tested β-caryophyllene oxide induced a significant increase of micronucleated cells with or without metabolic activation.  β-Caryophyllene oxide could be considered as a safe repellent, effective against mosquitoes.

Keywords: Excito-repellency test system; β-Caryophyllene oxide; Phototoxic; Genotoxic; Mosquitoes

Domains: Life Sciences [q-bio]

Jirod Nararak, Carole Di Giorgio, Chutipong Sukkanon, Valerie Mahiou-Leddet, Evelyne Ollivier, et al.. Excito-repellency and biological safety of β-caryophyllene oxide against Aedes albopictus and Anopheles dirus (Diptera: Culicidae). Acta Tropica, 2020, 210, pp.105556. ⟨10.1016/j.actatropica.2020.105556⟩. ⟨hal-02941392⟩