Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation

Abstract : Graphical Abstract Highlights d Active T cell p-enhancers are highly dynamic during differentiation d Enhancer diversity might function to select specific isoform expression d Loss of H3K27me3 combined with enhancer gain hallmark T cell identity d Promoter choice is regulated by the PRC2 polycomb complex during differentiation Correspondence muhammad.maqbool@manchester.ac. uk (M.A.M.), jean-christophe.andrau@igmm.cnrs.fr (J.-C.A.) In Brief Development and activation of T lymphocytes are coordinated by lineage-specific transcriptional programs. Here, Maqbool et al. performed a wide epigenomic and transcriptional analysis of mouse T cell differentiation. These data provide new insights into the role of multiple enhancers and PRC2 in controlling alternative promoter choice during differentiation.