Abstract : Graphical Abstract Highlights d Active T cell p-enhancers are highly dynamic during differentiation d Enhancer diversity might function to select specific isoform expression d Loss of H3K27me3 combined with enhancer gain hallmark T cell identity d Promoter choice is regulated by the PRC2 polycomb complex during differentiation Correspondence muhammad.maqbool@manchester.ac. uk (M.A.M.), jean-christophe.andrau@igmm.cnrs.fr (J.-C.A.) In Brief Development and activation of T lymphocytes are coordinated by lineage-specific transcriptional programs. Here, Maqbool et al. performed a wide epigenomic and transcriptional analysis of mouse T cell differentiation. These data provide new insights into the role of multiple enhancers and PRC2 in controlling alternative promoter choice during differentiation.
https://hal-amu.archives-ouvertes.fr/hal-03015018 Contributor : Lionel SpinelliConnect in order to contact the contributor Submitted on : Thursday, November 19, 2020 - 4:53:55 PM Last modification on : Friday, August 5, 2022 - 10:34:52 AM Long-term archiving on: : Saturday, February 20, 2021 - 8:24:12 PM
Muhammad Ahmad Maqbool, Léo Pioger, Amal Zine El Aabidine, Nezih Karasu, Anne Marie Molitor, et al.. Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation. Cell Reports, Elsevier Inc, 2020, 32, ⟨10.1016/j.celrep.2020.108048⟩. ⟨hal-03015018⟩