Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer

Rawand Masoud (1) , Gabriela Reyes-Castellanos (1) , Sophie Lac (1) , Julie Garcia (1) , Samir Dou (1) , Laetitia Shintu (2) , Nadine Abdel Hadi (1) , Tristan Gicquel (1) , Abdessamad El Kaoutari (1) , Binta Diémé (3) , Fabrice Tranchida (2) , Laurie Cormareche (1) , Laurence Borge (1) , Odile Gayet (1) , Eddy Pasquier (1) , Nelson Dusetti (1) , Juan Iovanna (1) , Alice Carrier (1)

1 CRCM - Centre de Recherche en Cancérologie de Marseille
2 ISM2 - Institut des Sciences Moléculaires de Marseille
3 PFEM - Plateforme Exploration du Métabolisme

Highlights d Pancreatic ductal adenocarcinoma (PDAC) displays OXPHOS heterogeneity d High OXPHOS PDAC tumors are enriched in mitochondrial respiratory complex I d Complex I inhibitor phenformin synergizes with chemotherapy in high OXPHOS cells d Phenformin cooperates with gemcitabine antitumoral activity in high OXPHOS tumors

Domaines: Sciences du Vivant [q-bio]

Rawand Masoud, Gabriela Reyes-Castellanos, Sophie Lac, Julie Garcia, Samir Dou, et al.. Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer. Cell Reports Medicine, 2020, 1 (8), pp.100143. ⟨10.1016/j.xcrm.2020.100143⟩. ⟨hal-03097443⟩