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Point of view: Should COVID-19 patients be supplemented with vitamin D?

Abstract : Using Hill's methodology for exploring causality, we aimed to determine in early May 2020 whether evidence supports vitamin D as a biological determinant of COVID-19 outcomes. Vitamin D is a secosteroid hormone theoretically able to reduce COVID-19 risk through regulation of (i) the renin-angiotensin system, (ii) cellular innate and adaptive immunity, and (iii) physical barriers. Inverse associations were found between 25-hydroxyvitamin D concentrations and COVID-19 incidence and mortality. Randomized controlled trials testing vitamin D supplementation in the treatment of COVID-19 are in progress. Positive results in such studies would encourage the use of vitamin D supplements as an adjuvant treatment in COVID-19.
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https://hal-amu.archives-ouvertes.fr/hal-03170726
Contributor : Ludovic Leloup <>
Submitted on : Tuesday, March 16, 2021 - 2:10:17 PM
Last modification on : Wednesday, July 21, 2021 - 9:48:02 AM

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Cédric Annweiler, Zhijian Cao, Jean-Marc Sabatier. Point of view: Should COVID-19 patients be supplemented with vitamin D?. Maturitas, Elsevier, 2020, 140, pp.24-26. ⟨10.1016/j.maturitas.2020.06.003⟩. ⟨hal-03170726⟩

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