Skip to Main content Skip to Navigation
New interface
Journal articles

Extracellular vesicle-enriched miRNA profiles across pregnancy in the MADRES cohort

Abstract : MicroRNA (miRNA) circulating in plasma have been proposed as biomarkers for a variety of conditions and diseases, including complications during pregnancy. During pregnancy, about 15–25% of maternal plasma exosomes, a small size-class of EVs, are hypothesized to originate in the placenta, and may play a role in communication between the fetus and mother. However, few studies have addressed changes in miRNA over the course of pregnancy with repeated measures, nor focused on diverse populations. We describe changes in miRNA in early and late pregnancy from the MADRES cohort of primarily low-income Hispanic women based in Los Angeles, CA. miRNA derived from extracellular-vesicles (EVs) were isolated from maternal blood plasma samples collected in early and late pregnancy. In this study, we identified 64 of 130 detectable miRNA which significantly increased with gestational age at the time of collection (GA), and 26 which decreased with GA. Possible fetal sex-specific associations were observed for 30 of these 90 significant miRNA. Predicted gene targets for miRNA significantly associated with GA were identified using MirDIP and were found to be enriched for Gene Ontology categories that included energetic and metabolic processes but were underrepresented in immune-related categories. Circulating EV-associated miRNA during pregnancy are likely important for maternal-fetal communication, and may play roles in supporting and maintaining a healthy pregnancy, given the changing needs of the fetus.
Document type :
Journal articles
Complete list of metadata
Contributor : Julien Caugant Connect in order to contact the contributor
Submitted on : Wednesday, May 26, 2021 - 1:50:51 PM
Last modification on : Tuesday, November 29, 2022 - 11:50:04 AM
Long-term archiving on: : Friday, August 27, 2021 - 7:38:43 PM


Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License




Helen Bermudez Foley, Caitlin G. Howe, Sandrah P. Eckel, Thomas Chavez, Lili Gevorkian, et al.. Extracellular vesicle-enriched miRNA profiles across pregnancy in the MADRES cohort. PLoS ONE, 2021, 16 (5), pp.e0251259. ⟨10.1371/journal.pone.0251259⟩. ⟨hal-03236743⟩



Record views


Files downloads