Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo

Olivier Dubanet (1) , Arnaldo Ferreira Gomes da Silva (1, 2) , Andreas Frick (1) , Hajime Hirase (3) , Anna Beyeler (1) , Xavier Leinekugel (1, 2)

1 U1215 Inserm - UB - Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale
2 INMED - INSERM U1249 - Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université]
3 ITU - IT University of Copenhagen

Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo Graphical abstract Highlights d CA3 PV-interneurons generate perisomatic unitary GABAergic field potentials in vivo d GABAergic unitary fields can be used to probe inhibition with single-cell resolution d GABA reversal after acute seizures is restricted to the postictal silent period d GABAergic excitation during KA epileptogenesis is restricted to 0.6% of CA3 neurons

Keywords: GABAergic transmission; inhibition; epilepsy; hippocampus; interneurons

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]

Olivier Dubanet, Arnaldo Ferreira Gomes da Silva, Andreas Frick, Hajime Hirase, Anna Beyeler, et al.. Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo. Cell Reports, 2021, 36 (2), pp.109381. ⟨10.1016/j.celrep.2021.109381⟩. ⟨hal-03328694⟩