Skip to Main content Skip to Navigation
Journal articles

Biocompatible analysis of marine magnetotactic ovoid strain MO-1 for in vivo application *

Abstract : Magnetotactic bacteria are capable of biosynthesizing magnetic nanoparticles, also called magnetosomes, and swimming along magnetic field lines. The abilities endow the whole cells of magnetotactic bacteria with such applications as targeted therapy and manipulation of microrobots. We have shown that the intact marine magnetotactic bacteria MO-1 kill efficiently antibiotic-resistant pathogen Staphylococcus aureus in vivo, but the biocompatibility of this marine bacteria is unknown. In this study, the strain MO-1 was chosen to analyze its biocompatibility and potential for biomedicine applications. Results showed that MO-1 cells could be guided at 37 °C under an external magnetic field and swim in the blood plasma and urine. They could keep active locomotivity within 40 minutes in the plasma and urine, although their velocity slowed down. When incubated with human cells, magnetotactic bacteria MO-1 had no obvious effects on cellular viability at low dose, while the cell toxicity increased with the augmentation of the quantity of the MO-1 cells added. In the in vivo experiments, the median lethal dose of magnetotactic bacteria MO-1 in rats was determined to be 7.9 × 10 10 cells/kg. These results provided the foundation for the biocompatibility and safety evaluations of magnetotactic bacteria MO-1 and suggested that they could be basically used in clinical targeted therapy.
Document type :
Journal articles
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03338462
Contributor : Delphine Leroi <>
Submitted on : Wednesday, September 8, 2021 - 4:27:59 PM
Last modification on : Friday, September 10, 2021 - 3:23:49 AM

Files

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2021-11-01

Please log in to resquest access to the document

Identifiers

  • HAL Id : hal-03338462, version 1

Collections

Citation

Chen Changyou, Wang Pingping, Long-Fei Wu, Song Tao. Biocompatible analysis of marine magnetotactic ovoid strain MO-1 for in vivo application *. Chinese Journal of Oceanology and Limnology, Springer Verlag, 2021. ⟨hal-03338462⟩

Share

Metrics

Record views

19