Skip to Main content Skip to Navigation
Journal articles

Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection

Abstract : Host protection against cutaneous herpes simplex virus 1 (HSV-1) infection relies on the induction of a robust adaptive immune response. Here, we show that Nav 1.8 + sensory neurons, which are involved in pain perception, control the magnitude of CD8 T cell priming and expansion in HSV-1-infected mice. The ablation of Nav 1.8-expressing sensory neurons is associated with extensive skin lesions characterized by enhanced inflammatory cytokine and chemokine production. Mechanistically, Nav 1.8 + sensory neurons are required for the downregulation of neutrophil infiltration in the skin after viral clearance to limit the severity of tissue damage and restore skin homeostasis, as well as for eliciting robust CD8 T cell priming in skin-draining lymph nodes by controlling dendritic cell responses. Collectively, our data reveal an important role for the sensory nervous system in regulating both innate and adaptive immune responses to viral infection, thereby opening up possibilities for new therapeutic strategies.
Document type :
Journal articles
Complete list of metadata
Contributor : Sébastien Poulain Connect in order to contact the contributor
Submitted on : Wednesday, October 27, 2021 - 4:48:07 PM
Last modification on : Friday, April 1, 2022 - 3:56:54 AM
Long-term archiving on: : Friday, January 28, 2022 - 7:23:04 PM


Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License




Jessica Filtjens, Anais Roger, Linda Quatrini, Elisabeth Wieduwild, Jordi Gouilly, et al.. Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection. Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-22841-6⟩. ⟨hal-03406154⟩



Record views


Files downloads