Mind the gap: from neurons to networks to outcomes in multiple sclerosis

Declan Chard (1, 2) , Adnan Alahmadi (3) , Bertrand Audoin (4, 5, 6) , Thalis Charalambous (1) , Christian Enzinger (7, 8) , Hanneke Hulst (9) , Maria Rocca (10) , Àlex Rovira (11) , Jaume Sastre-Garriga (11) , Menno Schoonheim (9) , Betty Tijms (12) , Carmen Tur (1, 13) , Claudia Gandini Wheeler-Kingshott (1, 14, 15) , Alle Meije Wink (16) , Olga Ciccarelli (1, 2) , Frederik Barkhof (2, 16, 17)

1 NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London
2 National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, London
3 Department of Diagnostic Radiology, Faculty of Applied Medical Science, King Abdulaziz University (KAU), Jeddah
4 CRMBM - Centre de résonance magnétique biologique et médicale
5 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM]
6 AP-HM, CHU Timone, Pole de Neurosciences Cliniques, Department of Neurology, Marseille, France.
7 Department of Neurology, Research Unit for Neuronal Repair and Plasticity, Medical University of Graz, Graz
8 Department of Radiology, Division of Neuroradiology, Vascular and Interventional Radiology, Medical University of Graz, Graz
9 Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam
10 Neuroimaging Research Unit and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan
11 UAB - Universitat Autònoma de Barcelona
12 Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam
13 Department of Neurology, Luton and Dunstable University Hospital, Luton
14 UNIPV - Università degli Studi di Pavia = University of Pavia
15 Brain MRI 3T Research Center, IRCCS Mondino Foundation, Pavia
16 Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam
17 UCL - University College of London [London]

Domains: Cognitive science; Neuroscience

Declan Chard, Adnan Alahmadi, Bertrand Audoin, Thalis Charalambous, Christian Enzinger, et al.. Mind the gap: from neurons to networks to outcomes in multiple sclerosis. Nature Reviews Neurology, 2021, 17 (3), pp.173-184. ⟨10.1038/s41582-020-00439-8⟩. ⟨hal-03501361⟩