Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease

Roxana Ameli; Charles R.G. Guttmann; Juan Carlos Prieto; Fabien Rollot; Miklos Palotai; Sandra Vukusic; Romain Marignier; François Cotton; René Anxionnat; Jean-Paul Armspach; Bertrand Audoin; Christian Barillot; Isabelle Berry; Fabrice Bonneville; Claire Boutet; Giovanni Castelnovo; Frédéric Cervenanski; Mikael Cohen; Olivier Commowick; Jerome de Seze; Vincent Dousset; Francoise Durand-Dubief; Gilles Edan; Jean-Christophe Ferré; Damien Galanaud; Tristan Glattard; Sylvie Grand; Justine Guillaumont; Rémy Guillevin; Salem Hannoun; Fabrice Heitz; Alexandre Krainik; Stéphane Kremer; Pierre Labauge; Nicolas Menjot de Champfleur; Jean-Philippe Ranjeva; Jean-Amédée Roch; Dominique Sappey-Marinier; Julien Savatovsky; Bruno Stankoff; Ayman Tourbah; Thomas Tourdias; Bruno Brochet; Michel Clanet; Nathalie Dufay; David Laplaud; Marie-Claire Maze; Thibault Moreau; Cédric Trolliet; Bernard Frangoulis; Javier Olaiz; Jean Pelletier; Bertrand Bourre; David Brassat; Philippe Cabre; Jean-Philippe Camdessanche; William Camu; Olivier Casez; Pierre Clavelou; Nicolas Collongues; Alain Creange; Gilles Defer; Marc Debouverie; Olivier Gout; Christine Lebrun-Frenay; Catherine Lubetzki; Caroline Papeix; Patrick Vermersch; Hélène Zephir

doi:10.1016/j.neurad.2019.03.015

Journal articles

Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease

Roxana Ameli ^{1, *} Charles R.G. Guttmann ² Juan Carlos Prieto ² Fabien Rollot ³ Miklos Palotai ² Sandra Vukusic ⁴ Romain Marignier ⁵ François Cotton ⁶ René Anxionnat ⁷ Jean-Paul Armspach ⁸ Bertrand Audoin ^{9, 10} Christian Barillot ¹¹ Isabelle Berry ¹² Fabrice Bonneville ¹³ Claire Boutet ¹⁴ Giovanni Castelnovo ¹⁵ Frédéric Cervenanski ⁶ Mikael Cohen ¹⁶ Olivier Commowick ¹¹ Jerome de Seze ¹⁷ Vincent Dousset ¹⁸ Francoise Durand-Dubief ⁶ Gilles Edan ¹¹ Jean-Christophe Ferré ¹¹ Damien Galanaud ¹⁵ Tristan Glattard ⁶ Sylvie Grand ¹⁹ Justine Guillaumont ¹¹ Rémy Guillevin ²⁰ Salem Hannoun ⁶ Fabrice Heitz ⁸ Alexandre Krainik ¹⁹ Stéphane Kremer ⁸ Pierre Labauge ²¹ Nicolas Menjot de Champfleur ²² Jean-Philippe Ranjeva ^{9, 10} Jean-Amédée Roch ²³ Dominique Sappey-Marinier ⁶ Julien Savatovsky ²⁴ Bruno Stankoff ²⁵ Ayman Tourbah ²⁶ Thomas Tourdias ¹⁸ Bruno Brochet ²⁷ Michel Clanet ²⁸ Nathalie Dufay ⁴ David Laplaud ²⁹ Marie-Claire Maze ⁴ Thibault Moreau ³⁰ Cédric Trolliet ³ Bernard Frangoulis ³¹ Javier Olaiz ³¹ Jean Pelletier ^{9, 10} Bertrand Bourre ³² David Brassat ¹³ Philippe Cabre ³³ Jean-Philippe Camdessanche ³⁴ William Camu ³⁵ Olivier Casez ³⁶ Pierre Clavelou ³⁷ Nicolas Collongues ³⁸ Alain Creange ³⁹ Gilles Defer ⁴⁰ Marc Debouverie ⁴¹ Olivier Gout ²⁴ Christine Lebrun-Frenay ¹⁶ Catherine Lubetzki ⁴² Caroline Papeix ⁴² Patrick Vermersch ⁴³ Hélène Zephir ⁴³

* Corresponding author

1 Service de Radiologie [Hôpital Femme Mère Enfant - HCL]

2 Department of Radiology [Boston]

3 OFSEP - Observatoire Français de la Sclérose En Plaques [Lyon]

4 Service de Neurologie [Lyon]

5 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center

6 CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé

7 IADI - Imagerie Adaptative Diagnostique et Interventionnelle

8 ICube - Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie

9 CRMBM - Centre de résonance magnétique biologique et médicale

10 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM]

11 Empenn

INSERM - Institut National de la Santé et de la Recherche Médicale, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE

12 Service de Médecine Nucléaire [Toulouse]

13 Pôle neurosciences [Hôpital de Purpan - Toulouse]

14 Service de radiologie [Saint-Etienne]

15 Service de Neuroradiologie [CHU Pitié-Salpêtrière]

16 Service de Neurologie [CHU Nice]

17 CHU Strasbourg

18 U1215 Inserm - UB - Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale

19 Service de neuroradiologie [Grenoble]

20 CHU Poitiers - Centre hospitalier universitaire de Poitiers

21 Département de neurologie [Montpellier]

22 I2FH - Institut d’Imagerie Fonctionnelle Humaine [CHU Montpellier]

23 Hôpital privé Jean Mermoz [Lyon]

24 Hôpital Rothschild [AP-HP]

25 CHU Tenon [AP-HP]

26 URCA - Université de Reims Champagne-Ardenne

27 Service de neurologie [Bordeaux]

28 Neurologie Vasculaire [Toulouse]

29 Service de neurochirurgie [Nantes]

30 Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)

31 Fondation Eugène Devic EDMUS

32 Hôpital Charles Nicolle [Rouen]

33 Hôpital Albert Clarac [CHU de la Martinique]

34 Hôpital Nord (Saint Etienne)

35 IBC - Institut de Biologie Computationnelle

36 Département de neurologie

37 Service de Neurologie [CHU Clermont-Ferrand]

38 Hôpital de Hautepierre [Strasbourg]

39 CHU Henri Mondor - Département de neurosciences

40 Service de Neurologie [CHU Caen]

41 Service de neurologie [CHRU Nancy]

42 Service de Neurologie [CHU Pitié-Salpêtrière]

43 Département de neurologie [Lille]

Abstract : Background and purposeTo determine the precise incidence of lesions at sites of high Aquaporin-4 expression (hAQP4) and their possible association with known neuromyelitis optica spectrum disease (NMOSD) lesions patterns.Materials and methodsA retrospective analysis of brain and, when available, spinal cord MRI scans of 54 NMOSD patients recruited among the French NMOSD cohort was performed. Brain lesions were annotated as MS-like, non-specific, or evocative of NMOSD. The topography of hAQP4 was reassessed by human brain atlas. The incidence of lesions in hAQP4 and their association with lesions evocative of NMOSD was estimated.ResultsAmong those included (41/54 female, mean age: 45 years) 47/54 (87%) presented brain lesions. Twenty-six/47 (55%) had lesions in hAQP4. Thirty-two/54 patients (60%) had lesions considered evocative of NMOSD. The majority of them also presented lesions in hAQP4 (65%, 21/32). Patients with lesions in hAQP4 and lesions evocative of NMOSD demonstrated more extensive myelitis compared to the other patients (7 [6–10] versus 4 [3–5] vertebral segments, P = 0.009).ConclusionThe coexistence of lesions evocative of NMOSD and in hAQP4 is associated with significantly more extensive myelitis, and might have pathophysiological and clinical significance.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Bioengineering / Imaging

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https://hal-amu.archives-ouvertes.fr/hal-03538467
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Submitted on : Friday, January 21, 2022 - 9:44:34 AM
Last modification on : Sunday, May 1, 2022 - 3:17:47 AM

Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease

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Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease

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