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Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease

Roxana Ameli 1, * Charles R.G. Guttmann 2 Juan Carlos Prieto 2 Fabien Rollot 3 Miklos Palotai 2 Sandra Vukusic 4 Romain Marignier 5 François Cotton 6 René Anxionnat 7 Jean-Paul Armspach 8 Bertrand Audoin 9, 10 Christian Barillot 11 Isabelle Berry 12 Fabrice Bonneville 13 Claire Boutet 14 Giovanni Castelnovo 15 Frédéric Cervenanski 6 Mikael Cohen 16 Olivier Commowick 11 Jerome de Seze 17 Vincent Dousset 18 Francoise Durand-Dubief 6 Gilles Edan 11 Jean-Christophe Ferré 11 Damien Galanaud 15 Tristan Glattard 6 Sylvie Grand 19 Justine Guillaumont 11 Rémy Guillevin 20 Salem Hannoun 6 Fabrice Heitz 8 Alexandre Krainik 19 Stéphane Kremer 8 Pierre Labauge 21 Nicolas Menjot de Champfleur 22 Jean-Philippe Ranjeva 9, 10 Jean-Amédée Roch 23 Dominique Sappey-Marinier 6 Julien Savatovsky 24 Bruno Stankoff 25 Ayman Tourbah 26 Thomas Tourdias 18 Bruno Brochet 27 Michel Clanet 28 Nathalie Dufay 4 David Laplaud 29 Marie-Claire Maze 4 Thibault Moreau 30 Cédric Trolliet 3 Bernard Frangoulis 31 Javier Olaiz 31 Jean Pelletier 9, 10 Bertrand Bourre 32 David Brassat 13 Philippe Cabre 33 Jean-Philippe Camdessanche 34 William Camu 35 Olivier Casez 36 Pierre Clavelou 37 Nicolas Collongues 38 Alain Creange 39 Gilles Defer 40 Marc Debouverie 41 Olivier Gout 24 Christine Lebrun-Frenay 16 Catherine Lubetzki 42 Caroline Papeix 42 Patrick Vermersch 43 Hélène Zephir 43
* Corresponding author
11 Empenn
INSERM - Institut National de la Santé et de la Recherche Médicale, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : Background and purposeTo determine the precise incidence of lesions at sites of high Aquaporin-4 expression (hAQP4) and their possible association with known neuromyelitis optica spectrum disease (NMOSD) lesions patterns.Materials and methodsA retrospective analysis of brain and, when available, spinal cord MRI scans of 54 NMOSD patients recruited among the French NMOSD cohort was performed. Brain lesions were annotated as MS-like, non-specific, or evocative of NMOSD. The topography of hAQP4 was reassessed by human brain atlas. The incidence of lesions in hAQP4 and their association with lesions evocative of NMOSD was estimated.ResultsAmong those included (41/54 female, mean age: 45 years) 47/54 (87%) presented brain lesions. Twenty-six/47 (55%) had lesions in hAQP4. Thirty-two/54 patients (60%) had lesions considered evocative of NMOSD. The majority of them also presented lesions in hAQP4 (65%, 21/32). Patients with lesions in hAQP4 and lesions evocative of NMOSD demonstrated more extensive myelitis compared to the other patients (7 [6–10] versus 4 [3–5] vertebral segments, P = 0.009).ConclusionThe coexistence of lesions evocative of NMOSD and in hAQP4 is associated with significantly more extensive myelitis, and might have pathophysiological and clinical significance.
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https://hal-amu.archives-ouvertes.fr/hal-03538467
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Submitted on : Friday, January 21, 2022 - 9:44:34 AM
Last modification on : Sunday, May 1, 2022 - 3:17:47 AM

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Roxana Ameli, Charles R.G. Guttmann, Juan Carlos Prieto, Fabien Rollot, Miklos Palotai, et al.. Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease. Journal de Neuroradiologie / Journal of Neuroradiology, Elsevier Masson, 2021, 48 (3), pp.170-175. ⟨10.1016/j.neurad.2019.03.015⟩. ⟨hal-03538467⟩

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