Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Raju Kapoor (1) , Pei-Ran Ho (2) , Nolan Campbell (2) , Ih Chang (2) , Aaron Deykin (2) , Fiona Forrestal (2) , Nisha Lucas (2) , Bei Yu (2) , Douglas Arnold (3) , Mark Freedman (4) , Myla Goldman (5) , Hans-Peter Hartung (6) , Eva Kubala Havrdová (7) , Douglas Jeffery (8) , Aaron Miller (9) , Finn Sellebjerg (10) , Diego Cadavid (2) , Dan Mikol (2) , Deborah Steiner (2) , Emmanuel Bartholomé , Marie d'Hooghe , Massimo Pandolfo , Bart van Wijmeersch , Virender Bhan , Gregg Blevins , Donald Brunet , Virginia Devonshire , Pierre Duquette , François Grand'Maison , François Jacques , Yves Lapierre , Liesly Lee , Sarah Morrow , Michael Yeung , Michal Dufek , Petr Kanovsky , Ivana Stetkarova , Marika Talabova , Jette Frederiksen , Matthias Kant , Thor Petersen , Mads Ravnborg , Laura Airas , Irina Elovaara , Juha-Pekka Eralinna , Taneli Sarasoja , Abdullatif Al Khedr , David Brassat , Bruno Brochet , William Camu , Marc Debouverie , David Laplaud , Christine Lebrun Frenay , Jean Pelletier (11, 12, 13) , Patrick Vermersch , Sandra Vukusi , Karl Baum , Achim Berthele , Juergen Faiss , Peter Flachenecker , Reinhard Hohlfeld , Markus Krumbholz , Christoph Lassek , Mathias Maeurer , Sven Meuth , Tjalf Ziemssen , Orla Hardiman , Christopher Mcguigan , Anat Achiron , Dimitrios Karussis , Roberto Bergamaschi , Vincenzo Brescia Morra , Giancarlo Comi , Salvatore Cottone , Luigi Grimaldi , Giovanni Luigi Mancardi , Luca Massacesi , Ugo Nocentini , Marco Salvetti , Elio Scarpini , Patrizia Sola , Gioacchino Tedeschi , Maria Trojano , Mauro Zaffaroni , Stephan Frequin , Raymond Hupperts , Joep Killestein , Hans Schrijver , Ronald van Dijl , Erik van Munster , Maciej Czarnecki , Wieslaw Drozdowski , Waldemar Fryze , Hanka Hertmanowska , Jan Ilkowski , Anna Kaminska , Gabriela Klodowska-Duda , Maciej Maciejowski , Ewa Motta , Ryszard Podemski , Andrzej Potemkowski , Teresa Rog , Krzysztof Selmaj , Zbigniew Stelmasiak , Adam Stepien , Andrzej Tutaj , Jacek Zaborski , Alexey Boyko , Zanna Chefranova , Evgeny Evdoshenko , Farit Khabirov , Stella Sivertseva , Eduard Yakupov , Jose Carlos Alvarez Cermeño , Antonio Escartin , Oscar Fernandez Fernandez , Antonio Garcia-Merino , Miguel Angel Hernandez Perez , Guillermo Izquierdo Ayuso , José Meca Lallana , Xavier Montalban Gairin , Celia Oreja-Guevara , Albert Saiz Hinarejos , Martin Gunnarsson , Jan Lycke , Claes Martin , Fredrik Piehl , Homayoun Roshanisefat , Peter Sundstrom , Martin Duddy , Bruno Gran , Timothy Harrower , Jeremy Hobart , Martin Lee , Paul Mattison , Richard Nicholas , Owen Pearson , Waqar Rashid , David Rog , Basil Sharrack , Eli Silber , Ben Turner , Anna Williams , John Woolmore , Carolyn Young , Daniel Bandari , Joseph Berger , Ann Camac , Stanley Cohan , Jill Conway , Keith Edwards , Michelle Fabian , Jack Florin , Steven Freedman , Dennis Garwacki , Daniel Harrison , Craig Herrman , Deren Huang , Adil Javed , Stephen Kamin , George Katsamakis , Bhupendra Khatri , Annette Langer-Gould , Sharon Lynch , David Mattson , Tamara Miller , Augusto Miravalle , Harold Moses , Suraj Muley , James Napier , Allen Nielsen , Andrew Pachner , Gabriel Pardo , Maryann Picone , Derrick Robertson , Walter Royal , Christopher Sheppard , Ben Thrower , Cary Twyman , Emmanuelle Waubant , Jeanette Wendt , Vijayshree Yadav , Rana Zabad , Greg Zarelli

1 National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London
2 Biogen Inc. [Cambridge, MA, USA]
3 Montreal Neurological Institute, Montreal, QC, Canada; NeuroRx Research, Montreal, QC
4 University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON
5 University of Virginia, Charlottesville, VA
6 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
7 First Faculty of Medicine-Charles University in Prague and General University Hospital in Prague
8 Piedmont HealthCare, Mooresville, NC
9 Icahn School of Medicine at Mount Sinai, New York, NY
10 UCPH - University of Copenhagen = Københavns Universitet
11 AP-HM, CHU Timone, Pole de Neurosciences Cliniques, Department of Neurology, Marseille, France.
12 CRMBM - Centre de résonance magnétique biologique et médicale
13 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM]

Domains: Life Sciences [q-bio]; Human health and pathology

Raju Kapoor, Pei-Ran Ho, Nolan Campbell, Ih Chang, Aaron Deykin, et al.. Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension. The Lancet Neurology, 2018, 17 (5), pp.405-415. ⟨10.1016/S1474-4422(18)30069-3⟩. ⟨hal-03541622⟩