Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Raju Kapoor; Pei-Ran Ho; Nolan Campbell; Ih Chang; Aaron Deykin; Fiona Forrestal; Nisha Lucas; Bei Yu; Douglas Arnold; Mark Freedman; Myla Goldman; Hans-Peter Hartung; Eva Kubala Havrdová; Douglas Jeffery; Aaron Miller; Finn Sellebjerg; Diego Cadavid; Dan Mikol; Deborah Steiner; Emmanuel Bartholomé; Marie d'Hooghe; Massimo Pandolfo; Bart van Wijmeersch; Virender Bhan; Gregg Blevins; Donald Brunet; Virginia Devonshire; Pierre Duquette; François Grand'Maison; François Jacques; Yves Lapierre; Liesly Lee; Sarah Morrow; Michael Yeung; Michal Dufek; Petr Kanovsky; Ivana Stetkarova; Marika Talabova; Jette Frederiksen; Matthias Kant; Thor Petersen; Mads Ravnborg; Laura Airas; Irina Elovaara; Juha-Pekka Eralinna; Taneli Sarasoja; Abdullatif Al Khedr; David Brassat; Bruno Brochet; William Camu; Marc Debouverie; David Laplaud; Christine Lebrun Frenay; Jean Pelletier; Patrick Vermersch; Sandra Vukusi; Karl Baum; Achim Berthele; Juergen Faiss; Peter Flachenecker; Reinhard Hohlfeld; Markus Krumbholz; Christoph Lassek; Mathias Maeurer; Sven Meuth; Tjalf Ziemssen; Orla Hardiman; Christopher Mcguigan; Anat Achiron; Dimitrios Karussis; Roberto Bergamaschi; Vincenzo Brescia Morra; Giancarlo Comi; Salvatore Cottone; Luigi Grimaldi; Giovanni Luigi Mancardi; Luca Massacesi; Ugo Nocentini; Marco Salvetti; Elio Scarpini; Patrizia Sola; Gioacchino Tedeschi; Maria Trojano; Mauro Zaffaroni; Stephan Frequin; Raymond Hupperts; Joep Killestein; Hans Schrijver; Ronald van Dijl; Erik van Munster; Maciej Czarnecki; Wieslaw Drozdowski; Waldemar Fryze; Hanka Hertmanowska; Jan Ilkowski; Anna Kaminska; Gabriela Klodowska-Duda; Maciej Maciejowski; Ewa Motta; Ryszard Podemski; Andrzej Potemkowski; Teresa Rog; Krzysztof Selmaj; Zbigniew Stelmasiak; Adam Stepien; Andrzej Tutaj; Jacek Zaborski; Alexey Boyko; Zanna Chefranova; Evgeny Evdoshenko; Farit Khabirov; Stella Sivertseva; Eduard Yakupov; Jose Carlos Alvarez Cermeño; Antonio Escartin; Oscar Fernandez Fernandez; Antonio Garcia-Merino; Miguel Angel Hernandez Perez; Guillermo Izquierdo Ayuso; José Meca Lallana; Xavier Montalban Gairin; Celia Oreja-Guevara; Albert Saiz Hinarejos; Martin Gunnarsson; Jan Lycke; Claes Martin; Fredrik Piehl; Homayoun Roshanisefat; Peter Sundstrom; Martin Duddy; Bruno Gran; Timothy Harrower; Jeremy Hobart; Martin Lee; Paul Mattison; Richard Nicholas; Owen Pearson; Waqar Rashid; David Rog; Basil Sharrack; Eli Silber; Ben Turner; Anna Williams; John Woolmore; Carolyn Young; Daniel Bandari; Joseph Berger; Ann Camac; Stanley Cohan; Jill Conway; Keith Edwards; Michelle Fabian; Jack Florin; Steven Freedman; Dennis Garwacki; Daniel Harrison; Craig Herrman; Deren Huang; Adil Javed; Stephen Kamin; George Katsamakis; Bhupendra Khatri; Annette Langer-Gould; Sharon Lynch; David Mattson; Tamara Miller; Augusto Miravalle; Harold Moses; Suraj Muley; James Napier; Allen Nielsen; Andrew Pachner; Gabriel Pardo; Maryann Picone; Derrick Robertson; Walter Royal; Christopher Sheppard; Ben Thrower; Cary Twyman; Emmanuelle Waubant; Jeanette Wendt; Vijayshree Yadav; Rana Zabad; Greg Zarelli

doi:10.1016/S1474-4422(18)30069-3

Journal articles

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Raju Kapoor ¹ Pei-Ran Ho ² Nolan Campbell ² Ih Chang ² Aaron Deykin ² Fiona Forrestal ² Nisha Lucas ² Bei Yu ² Douglas Arnold ³ Mark Freedman ⁴ Myla Goldman ⁵ Hans-Peter Hartung ⁶ Eva Kubala Havrdová ⁷ Douglas Jeffery ⁸ Aaron Miller ⁹ Finn Sellebjerg ¹⁰ Diego Cadavid ² Dan Mikol ² Deborah Steiner ² Emmanuel Bartholomé Marie d'Hooghe Massimo Pandolfo Bart van Wijmeersch Virender Bhan Gregg Blevins Donald Brunet Virginia Devonshire Pierre Duquette François Grand'Maison François Jacques Yves Lapierre Liesly Lee Sarah Morrow Michael Yeung Michal Dufek Petr Kanovsky Ivana Stetkarova Marika Talabova Jette Frederiksen Matthias Kant Thor Petersen Mads Ravnborg Laura Airas Irina Elovaara Juha-Pekka Eralinna Taneli Sarasoja Abdullatif Al Khedr David Brassat Bruno Brochet William Camu Marc Debouverie David Laplaud Christine Lebrun Frenay Jean Pelletier ^{11, 12, 13} Patrick Vermersch Sandra Vukusi Karl Baum Achim Berthele Juergen Faiss Peter Flachenecker Reinhard Hohlfeld Markus Krumbholz Christoph Lassek Mathias Maeurer Sven Meuth Tjalf Ziemssen Orla Hardiman Christopher Mcguigan Anat Achiron Dimitrios Karussis Roberto Bergamaschi Vincenzo Brescia Morra Giancarlo Comi Salvatore Cottone Luigi Grimaldi Giovanni Luigi Mancardi Luca Massacesi Ugo Nocentini Marco Salvetti Elio Scarpini Patrizia Sola Gioacchino Tedeschi Maria Trojano Mauro Zaffaroni Stephan Frequin Raymond Hupperts Joep Killestein Hans Schrijver Ronald van Dijl Erik van Munster Maciej Czarnecki Wieslaw Drozdowski Waldemar Fryze Hanka Hertmanowska Jan Ilkowski Anna Kaminska Gabriela Klodowska-Duda Maciej Maciejowski Ewa Motta Ryszard Podemski Andrzej Potemkowski Teresa Rog Krzysztof Selmaj Zbigniew Stelmasiak Adam Stepien Andrzej Tutaj Jacek Zaborski Alexey Boyko Zanna Chefranova Evgeny Evdoshenko Farit Khabirov Stella Sivertseva Eduard Yakupov Jose Carlos Alvarez Cermeño Antonio Escartin Oscar Fernandez Fernandez Antonio Garcia-Merino Miguel Angel Hernandez Perez Guillermo Izquierdo Ayuso José Meca Lallana Xavier Montalban Gairin Celia Oreja-Guevara Albert Saiz Hinarejos Martin Gunnarsson Jan Lycke Claes Martin Fredrik Piehl Homayoun Roshanisefat Peter Sundstrom Martin Duddy Bruno Gran Timothy Harrower Jeremy Hobart Martin Lee Paul Mattison Richard Nicholas Owen Pearson Waqar Rashid David Rog Basil Sharrack Eli Silber Ben Turner Anna Williams John Woolmore Carolyn Young Daniel Bandari Joseph Berger Ann Camac Stanley Cohan Jill Conway Keith Edwards Michelle Fabian Jack Florin Steven Freedman Dennis Garwacki Daniel Harrison Craig Herrman Deren Huang Adil Javed Stephen Kamin George Katsamakis Bhupendra Khatri Annette Langer-Gould Sharon Lynch David Mattson Tamara Miller Augusto Miravalle Harold Moses Suraj Muley James Napier Allen Nielsen Andrew Pachner Gabriel Pardo Maryann Picone Derrick Robertson Walter Royal Christopher Sheppard Ben Thrower Cary Twyman Emmanuelle Waubant Jeanette Wendt Vijayshree Yadav Rana Zabad Greg Zarelli

1 National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London

2 Biogen Inc. [Cambridge, MA, USA]

3 Montreal Neurological Institute, Montreal, QC, Canada; NeuroRx Research, Montreal, QC

4 University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON

5 University of Virginia, Charlottesville, VA

6 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]

7 First Faculty of Medicine-Charles University in Prague and General University Hospital in Prague

8 Piedmont HealthCare, Mooresville, NC

9 Icahn School of Medicine at Mount Sinai, New York, NY

10 UCPH - University of Copenhagen = Københavns Universitet

11 AP-HM, CHU Timone, Pole de Neurosciences Cliniques, Department of Neurology, Marseille, France.

12 CRMBM - Centre de résonance magnétique biologique et médicale

13 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM]

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Human health and pathology

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https://hal-amu.archives-ouvertes.fr/hal-03541622
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Submitted on : Monday, January 24, 2022 - 5:52:26 PM
Last modification on : Monday, October 17, 2022 - 9:44:05 AM

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

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Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

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