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Les granules de stress, des acteurs émergents en cancérologie

Abstract : Cancer cells are submitted to numerous stresses during tumor development, such as hypoxia, lack of nutrient, oxidative stress, or mechanical constriction. A complex mechanism termed the integrated stress response (ISR) occurs allowing cell survival. This mechanism leads to the formation of membraneless cytoplasmic structures called stress granules. The hypothesis that these structures play a major role during tumorigenesis has recently emerged. Here, we describe the biological function of stress granules and of proteins that their formation. We also present the current evidences for their involvement in the development of tumors and in the tumor resistance to cancer drugs. Finally, we discuss the interest of targeting stress granule formation to enhance treatment efficiency in order to delay tumor progression.
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Submitted on : Friday, March 11, 2022 - 5:55:39 PM
Last modification on : Friday, April 1, 2022 - 3:55:07 AM

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Pauline Chavrier, Emilie Mamessier, Anaïs Aulas. Les granules de stress, des acteurs émergents en cancérologie. médecine/sciences, EDP Sciences, 2021, 37 (8-9), pp.735-741. ⟨10.1051/medsci/2021109⟩. ⟨hal-03606423⟩

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