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In Vivo Characterization of Neurophysiological Diversity in the Lateral Supramammillary Nucleus during Hippocampal Sharp-wave Ripples of Adult Rats

Abstract : The extent of the networks that control the genesis and modulation of hippocampal sharp-wave ripples (SPW-Rs), which are involved in memory consolidation, remains incompletely understood. Here, we performed a detailed in vivo analysis of single cell firing in the lateral supramammillary nucleus (lSuM) during theta and slow oscillations, including SPW-Rs, in anesthetized rats. We classified neurons as SPW-R-active and SPW-R unchanged according to whether or not they increased their firing during SPW-Rs. We show that lSuM SPW-R active neurons increase their firing prior to SPW-Rs peak power and prior to hippocampal excitatory cell activation. Moreover, lSuM SPW-R-active neurons show increased firing activity during theta and slow oscillations as compared to unchanged neurons. These results suggest that a sub-population of lSuM neurons can interact with the hippocampus during SPW-Rs, raising the possibility that the lSuM may modulate memory consolidation.
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https://hal-amu.archives-ouvertes.fr/hal-03626492
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Submitted on : Thursday, March 31, 2022 - 3:40:41 PM
Last modification on : Tuesday, April 5, 2022 - 1:57:39 PM
Long-term archiving on: : Friday, July 1, 2022 - 7:15:26 PM

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Ana F Vicente, Andrea Slézia, Antoine Ghestem, Christophe Bernard, Pascale P. Quilichini. In Vivo Characterization of Neurophysiological Diversity in the Lateral Supramammillary Nucleus during Hippocampal Sharp-wave Ripples of Adult Rats. Neuroscience, Elsevier - International Brain Research Organization, 2020, 435, pp.95 - 111. ⟨10.1016/j.neuroscience.2020.03.034⟩. ⟨hal-03626492⟩

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