Skip to Main content Skip to Navigation
New interface
Journal articles

NUPR1: A Critical Regulator of the Antioxidant System

Abstract : Nuclear protein 1 (NUPR1) is a small intrinsically disordered protein (IDP) activated in response to various types of cellular stress, including endoplasmic reticulum (ER) stress and oxidative stress. Reactive oxygen species (ROS) are mainly produced during mitochondrial oxidative metabolism, and directly impact redox homeostasis and oxidative stress. Ferroptosis is a ROS-dependent programmed cell death driven by an iron-mediated redox reaction. Substantial evidence supports a maintenance role of the stress-inducible protein NUPR1 on cancer cell metabolism that confers chemotherapeutic resistance by upregulating mitochondrial function-associated genes and various antioxidant genes in cancer cells. NUPR1, identified as an antagonist of ferroptosis, plays an important role in redox reactions. This review summarizes the current knowledge on the mechanism behind the observed impact of NUPR1 on mitochondrial function, energy metabolism, iron metabolism, and the antioxidant system. The therapeutic potential of genetic or pharmacological inhibition of NUPR1 in cancer is also discussed. Understanding the role of NUPR1 in the antioxidant system and the mechanisms behind its regulation of ferroptosis may promote the development of more efficacious strategies for cancer therapy.
Document type :
Journal articles
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03627323
Contributor : Carine Dou Goarin Connect in order to contact the contributor
Submitted on : Friday, April 1, 2022 - 11:16:49 AM
Last modification on : Saturday, April 2, 2022 - 3:34:11 AM

Links full text

Identifiers

Collections

Citation

Can Huang, Patricia Santofimia-Castaño, Juan Iovanna. NUPR1: A Critical Regulator of the Antioxidant System. Cancers, 2021, 13 (15), pp.3670. ⟨10.3390/cancers13153670⟩. ⟨hal-03627323⟩

Share

Metrics

Record views

5