Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

Hani Harb (1, 2) , Mehdi Benamar (3, 2) , Peggy Lai (4, 5) , Paola Contini (6, 7) , Jason Griffith (4, 5) , Elena Crestani (1, 2) , Klaus Schmitz-Abe (1, 2) , Qian Chen (1, 2) , Jason Fong (1, 2) , Luca Marri (7) , Gilberto Filaci (7) , Genny del Zotto (8) , Novalia Pishesha (2, 9) , Stephen Kolifrath (2, 9) , Achille Broggi (1, 10, 2) , Sreya Ghosh (1, 2) , Metin Yusuf Gelmez (11) , Fatma Betul Oktelik (11) , Esin Aktas Cetin (11) , Ayca Kiykim (12) , Murat Kose (13) , Ziwei Wang (1, 2) , Ye Cui (1, 2) , Xu Yu (14, 15) , Jonathan Li (15) , Lorenzo Berra (15) , Emmanuel Stephen-Victor (1, 2) , Louis-Marie Charbonnier (1, 2) , Ivan Zanoni (1, 2) , Hidde Ploegh (9) , Gunnur Deniz (11) , Raffaele de Palma (6, 7) , Talal Chatila (1, 2)

1 Boston Childrens Hosp, Division Immunology
2 Harvard Med Sch, Department pediatric
3 Boston Childrens Hosp, Division Immunology
4 Massachusetts General Hospital, Div Pulm & Crit Care
5 Harvard Medical School - department medical
6 University Genoa, Dept Internal Medical
7 IRCCS Ospedale Policlinico San Martino [Genoa, Italy]
8 IRCCS Istituto Giannina Gaslini [Genoa, Italy]
9 Boston Childrens Hospital
10 CIML - Centre d'Immunologie de Marseille - Luminy
11 Istanbul Univ, Aziz Sancar Inst Expt Med Aziz Sancar DETAE
12 Istanbul Univ Cerrahpasa, Fac Med, Div Pediat Allergy & Immunol
13 Istanbul Univ, Fac Med, Dept Internal Med
14 MIT - Massachusetts Institute of Technology
15 HMS - Harvard Medical School [Boston]

Domaines: Sciences du Vivant [q-bio]

Hani Harb, Mehdi Benamar, Peggy Lai, Paola Contini, Jason Griffith, et al.. Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. Immunity, 2021, 54 (6), pp.1186-1199.e7. ⟨10.1016/j.immuni.2021.04.002⟩. ⟨hal-03659276⟩