HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens

Abstract : Antibiotics are majorly important molecules for human health. Following the golden age of antibiotic discovery, a period of decline ensued, characterised by the rediscovery of the same molecules. At the same time, new culture techniques and high-throughput sequencing enabled the discovery of new microorganisms that represent a potential source of interesting new antimicrobial substances to explore. The aim of this review is to present recently discovered nonribosomal peptide (NRP) and polyketide (PK) molecules with antimicrobial activity against human pathogens. We highlight the different in silico/in vitro strategies and approaches that led to their discovery. As a result of technological progress and a better understanding of the NRP and PK synthesis mechanisms, these new antibiotic compounds provide an additional option in human medical treatment and a potential way out of the impasse of antibiotic resistance.
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03662607
Contributor : Isabelle Combe Connect in order to contact the contributor
Submitted on : Monday, May 9, 2022 - 2:29:32 PM
Last modification on : Tuesday, May 10, 2022 - 3:47:04 AM

Links full text

Identifiers

Collections

Citation

Sami Khabthani, Jean-Marc Rolain, Vicky Merhej. In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens. Microorganisms, MDPI, 2021, 9 (11), pp.2297. ⟨10.3390/microorganisms9112297⟩. ⟨hal-03662607⟩

Share

Metrics

Record views

0