The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

Jack Mccowan (1, 2) , Frédéric Fercoq (3) , Phoebe Kirkwood (1, 2) , Wouter T’jonck (1, 2) , Lizi Hegarty (1, 2) , Connar Mawer (1) , Richard Cunningham (1, 2) , Ananda Mirchandani (1, 2) , Anna Hoy (1, 2) , Duncan Humphries (1, 2) , Gareth-Rhys Jones (1, 2) , Carsten Hansen (1, 2) , Nik Hirani (1, 2) , Stephen Jenkins (1, 2) , Sandrine Henri (4) , Bernard Malissen (4, 5) , Sarah Walmsley (1, 2) , David Dockrell (1, 2) , Philippa Saunders (1, 2) , Leo Carlin (3, 6) , Calum Bain (1, 2)

1 MRC Centre for Regenerative Medicine and Multiple Sclerosis Society/University of Edinburgh Centre for Translational Research, Centre for Inflammation Research, The Queen’s Medical Research Institute, Edinburgh, UK.
2 University of Edinburgh
3 Cancer Research UK Beatson Institute [Glasgow]
4 CIML - Centre d'Immunologie de Marseille - Luminy
5 CIPHE - Centre d'Immunophénomique
6 Institute of Cancer Sciences, University of Glasgow

EGR2 controls alveolar macrophage function in health and disease.

Domains: Life Sciences [q-bio]

Jack Mccowan, Frédéric Fercoq, Phoebe Kirkwood, Wouter T’jonck, Lizi Hegarty, et al.. The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair. Science Immunology, 2021, 6 (65), ⟨10.1126/sciimmunol.abj2132⟩. ⟨hal-03666009⟩