The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

Jack Mccowan; Frédéric Fercoq; Phoebe Kirkwood; Wouter T’jonck; Lizi Hegarty; Connar Mawer; Richard Cunningham; Ananda Mirchandani; Anna Hoy; Duncan Humphries; Gareth-Rhys Jones; Carsten Hansen; Nik Hirani; Stephen Jenkins; Sandrine Henri; Bernard Malissen; Sarah Walmsley; David Dockrell; Philippa Saunders; Leo Carlin; Calum Bain

doi:10.1126/sciimmunol.abj2132

Journal articles

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

Jack Mccowan ^{1, 2} Frédéric Fercoq ³ Phoebe Kirkwood ^{1, 2} Wouter T’jonck ^{1, 2} Lizi Hegarty ^{1, 2} Connar Mawer ¹ Richard Cunningham ^{1, 2} Ananda Mirchandani ^{1, 2} Anna Hoy ^{1, 4} Duncan Humphries ^{1, 2} Gareth-Rhys Jones ^{1, 2} Carsten Hansen ^{1, 2} Nik Hirani ^{1, 2} Stephen Jenkins ^{1, 2} Sandrine Henri ⁵ Bernard Malissen ^{5, 6} Sarah Walmsley ^{1, 2} David Dockrell ^{1, 2} Philippa Saunders ^{1, 2} Leo Carlin ^{3, 7} Calum Bain ^{1, 2}

1 MRC Centre for Regenerative Medicine and Multiple Sclerosis Society/University of Edinburgh Centre for Translational Research, Centre for Inflammation Research, The Queen’s Medical Research Institute, Edinburgh, UK.

2 Institute for Regeneration and Repair, University of Edinburgh

3 Cancer Research UK Beatson Institute [Glasgow]

4 Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh

5 CIML - Centre d'Immunologie de Marseille - Luminy

6 CIPHE - Centre d'Immunophénomique

7 Institute of Cancer Sciences, University of Glasgow

Abstract : EGR2 controls alveolar macrophage function in health and disease.

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Journal articles

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Life Sciences [q-bio]

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The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

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The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

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