NMR and DFT Studies with a Doubly Labelled 15 N/ 6 Li S ‐Trifluoromethyl Sulfoximine Reveal Why a Directed ortho ‐Lithiation Requires an Excess of n ‐BuLi

Matthieu Hédouin (1) , Anne‐laure Barthelemy (2) , Nicolas Vanthuyne (3) , Hend Besrour (1) , Jacques Maddaluno (1) , Emmanuel Magnier (2) , Hassan Oulyadi (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 ILV - Institut Lavoisier de Versailles
3 ISM2 - Institut des Sciences Moléculaires de Marseille

Domains: Chemical Sciences

Matthieu Hédouin, Anne‐laure Barthelemy, Nicolas Vanthuyne, Hend Besrour, Jacques Maddaluno, et al.. NMR and DFT Studies with a Doubly Labelled 15 N/ 6 Li S ‐Trifluoromethyl Sulfoximine Reveal Why a Directed ortho ‐Lithiation Requires an Excess of n ‐BuLi. Angewandte Chemie International Edition, 2023, 62, pp.e202214106. ⟨10.1002/anie.202214106⟩. ⟨hal-03912827⟩