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Journal Articles Organic Letters Year : 2022

Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment

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Abstract

Apratoxin A is a potent anticancer natural product whose key polyketide fragment constitutes a considerable challenge for organic synthesis, with five prior syntheses requiring 12 to 20 steps for its preparation. By combining di erent redoxeconomical catalytic stereoselective transformations, the key polyketide fragment could be rapidly prepared. Followed by a siteselective protection of the diol, this strategy enables the preparation of the apratoxin A fragment in only six steps, representing the shortest route to this polyketide.
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hal-03955366 , version 1 (25-01-2023)

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Na Shao, Jean Rodriguez, Adrien Quintard. Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment. Organic Letters, 2022, 24 (36), pp.6537-6542. ⟨10.1021/acs.orglett.2c02482⟩. ⟨hal-03955366⟩

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