A unique array of neuroprotective effects of pyruvate in neuropathology

Yuri Zilberter (1) , Olena Gubkina (1) , Anton I. Ivanov (1)

1 INS - Institut de Neurosciences des Systèmes

The three common signature characteristics of many neurological diseases are brain hypometabolism, oxidative stress, and neuroinflammation (Melo et al., 2011; Cai et al., 2012; Heneka et al., 2014). In order to be efficient, successful treatment should target all three pathologies simultaneously. Pyruvate seems to be an ideal candidate for such a treatment because of its unique combination of neuroprotective effects (Figure 1). In this opinion paper, we attempt to review and summarize recent information concerning these effects and their significance for neuroprotection.

Keywords: energy metabolism; pyruvate; neurodegeneration; oxidative stress; PARP-1; NAD; neuroinflammation; TRAUMATIC BRAIN-INJURY; NEURONAL DEATH; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; THERAPEUTIC TARGETS; NAD(+) DEPLETION; GLUTAMATE; EPILEPSY; PROTECTION; DAMAGE

Domains: Neurons and Cognition [q-bio.NC]

Yuri Zilberter, Olena Gubkina, Anton I. Ivanov. A unique array of neuroprotective effects of pyruvate in neuropathology. Frontiers in Aging Neuroscience, 2015, 9 (17), ⟨10.3389/fnins.2015.00017⟩. ⟨hal-01219811⟩