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Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives

Abstract : We report herein the first synthesis of propargylic alcohols using an organic reducing agent. Diarylbutynol derivatives are formed in moderate to good yields under mild conditions from the reaction of 1-(3-chloroprop-1-ynyl)-4-nitrobenzene with various aromatic aldehydes using tetrakis(dimethylamino) ethylene (TDAE) as reductant.
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https://hal-amu.archives-ouvertes.fr/hal-01460469
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Submitted on : Tuesday, February 7, 2017 - 4:43:35 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:19 PM

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Manon Roche, Thierry Terme, Patrice Vanelle. Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives. Molecules, MDPI, 2013, 18 (2), pp.1540--1548. ⟨10.3390/molecules18021540⟩. ⟨hal-01460469⟩

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