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Post-operative nomogram for predicting freedom from recurrence after surgery in localised breast cancer receiving adjuvant hormone therapy.

C Mazouni 1 F Fina 2 S Romain 2 P Bonnier 3 L Ouafik 2 P-M Martin 2
1 IGR - Institut Gustave Roussy
2 Laboratoire de Transfert d'Oncologie Biologique [Hôpital Nord - APHM]
3 CHPB - Centre Hospitalier Privé Beauregard.
Abstract : PURPOSE: To develop a prognostic nomogram to predict freedom from recurrence for patients treated with adjuvant hormonal therapy (HT) for localised breast cancer (BC). METHODS: We performed a retrospective analysis of 142 patients treated with adjuvant HT between 1996 and 2000. Clinical and pathological parameters were analysed. RESULTS: A nomogram that predicts the probability of remaining free of recurrence for 5 years after surgery with adjuvant HT was developed using a Cox proportional hazards regression model. The progesterone receptor status (p < 0.001), nodal status (p = 0.008) and cathepsin-D (p < 0.001) were retained to construct the nomogram (C-index 0.734). CONCLUSIONS: The nomogram we developed may be useful for estimating the probability of successful treatment 5 years after surgery for localised BC.
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https://hal-amu.archives-ouvertes.fr/hal-01480127
Contributor : l'Houcine Ouafik <>
Submitted on : Tuesday, March 7, 2017 - 3:14:42 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:25 PM

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UNIV-AMU | FNCLCC | IGR | UNIV-PARIS-SACLAY | INP | INP-ATME

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C Mazouni, F Fina, S Romain, P Bonnier, L Ouafik, et al.. Post-operative nomogram for predicting freedom from recurrence after surgery in localised breast cancer receiving adjuvant hormone therapy.. Journal of Cancer Research and Clinical Oncology, Springer Verlag, 2015, 141 (6), pp.1083-1088. ⟨10.1007/s00432-014-1889-7⟩. ⟨hal-01480127⟩

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