Sudden Death Related to Toxicity in a Patient on Capecitabine and Irinotecan Plus Bevacizumab Intake: Pharmacogenetic Implications

Laetitia Dahan (1) , Joseph Ciccolini (2, 1) , Alexandre Evrard (3) , Litaty Mbatchi (3) , Jack Tibbitts (4) , Pauline Ries (5) , Emmanuelle Norguet (5) , Cédric Mercier (6, 1) , Athanassios Iliadis (6, 1) , L'Houcine Ouafik (1) , Bruno Lacarelle (6, 1) , Jean-François Seitz (7, 1)

1 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
2 SMARTc unit - Simulation & Modelling : Adaptive Response for Therapeutics in Cancer
3 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
4 Genentech, Inc.
5 TIMONE - Hôpital de la Timone [CHU - APHM]
6 Pharmacocinétique Toxicocinétique - [Hôpital de la Timone - APHM]
7 Service d'oncologie digestive et hépato-gastro-entérologie [Hôpital de la Timone - APHM]

Domains: Cancer

Laetitia Dahan, Joseph Ciccolini, Alexandre Evrard, Litaty Mbatchi, Jack Tibbitts, et al.. Sudden Death Related to Toxicity in a Patient on Capecitabine and Irinotecan Plus Bevacizumab Intake: Pharmacogenetic Implications. Journal of Clinical Oncology, 2012, 30 (4), pp.e41 - e44. ⟨10.1200/JCO.2011.37.9289⟩. ⟨hal-01707728⟩