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Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice

Thomas Del'Guidice Morgane Lemasson Adeline Etievant 1 Stella Manta 2 Luiz Alexandre V Magno Guy Escoffier 3 François Roman 4 Jean-Martin Beaulieu Thomas Del’guidice Luiz Alexandre V. Magno
1 U846 Inserm - UCBL1 - Institut cellule souche et cerveau
2 IPMC - Institut de pharmacologie moléculaire et cellulaire
3 NICN - Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN
4 NIA - Neurobiologie intégrative et adaptative
Abstract : Psychostimulants such as amphetamine and methylphenidate, which target the dopamine transporter (DAT), are the most frequently used drugs for the treatment of hyperactivity and cognitive deficits in humans with attention deficit hyperactivity disorder (ADHD). While psychostimulants can increase activity in healthy subjects, they exert a "paradoxical" calming effect in humans with ADHD as well as in hyperactive mice lacking the dopamine transporter (DAT-KO mice). However, the mechanism of action of these drugs and their impact on cognition in the absence of DAT remain poorly understood.
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https://hal-amu.archives-ouvertes.fr/hal-01770083
Contributor : Guy Escoffier <>
Submitted on : Wednesday, April 18, 2018 - 3:47:22 PM
Last modification on : Tuesday, October 13, 2020 - 3:10:42 AM

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Thomas Del'Guidice, Morgane Lemasson, Adeline Etievant, Stella Manta, Luiz Alexandre V Magno, et al.. Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice. Psychopharmacology, Springer Verlag, 2014, 231 (1), pp.109 - 122. ⟨10.1007/s00213-013-3212-8⟩. ⟨hal-01770083⟩

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