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Localization of the Gene Encoding Peptidylglycine α-Amidating Monooxygenase (PAM) to Human Chromosome 5q14-5q21

Abstract : Peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) is a multifunctional protein containing two enzymes that act sequentially to catalyze the alpha-amidation of neuroendocrine peptides. Southern blot analysis of human placental DNA demonstrated that PAM is encoded by a single gene. The chromosomal localization of the PAM gene was established using in situ hybridization. A 2.2-kb human PAM cDNA hybridized to human metaphase chromosomes revealed a significant clustering of silver grains over chromosome 5 bands q14-q21. The gene encoding another enzyme important in the post-translational processing of neuroendocrine precursors, prohormone convertase 1 (PC1), is localized in the same region (5q15-q21).
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https://hal-amu.archives-ouvertes.fr/hal-01807998
Contributor : l'Houcine Ouafik <>
Submitted on : Tuesday, June 5, 2018 - 1:48:16 PM
Last modification on : Friday, August 2, 2019 - 2:14:02 PM

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l'Houcine Ouafik, Marie Geneviève Mattei, Pierre Giraud, Charles Oliver, Betty Eipper, et al.. Localization of the Gene Encoding Peptidylglycine α-Amidating Monooxygenase (PAM) to Human Chromosome 5q14-5q21. Genomics, Elsevier, 1993, 18 (2), pp.319 - 321. ⟨10.1006/geno.1993.1471⟩. ⟨hal-01807998⟩

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