Impact of salpingectomy for ectopic pregnancy on the ovarian response during IVF stimulation

Camille Gay (1, 2) , Jeanne Perrin (2, 3) , Blandine Courbiere (2, 3) , Florence Bretelle (1, 4) , Aubert Agostini (1)

1 APHM - Assistance Publique - Hôpitaux de Marseille
2 Centre Clinico-Biologique d’Assistance Médicale à la Procréation - CECOS [Hôpital de la Conception - APHM]
3 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
4 MEPHI - Microbes évolution phylogénie et infections

Introduction Ovarian reserve is a major prognosic factor for Medical Assisted Procreation. Tubal surgery, realised close to mesosalpinx and ovarian vascularization, could impare ovarian function. However, salpingectomy is currently used to treat ectopic pregnancies or hydrosalpinx before IVF attempt. Disponible studies on this subject are unclear. The aim of this study is to evaluate the impact of salpingectomy for ectopic pregnancy on the ovarian response during IVF attempt. Material and methods It was a single center comparative study. Included patients were the one receiving oocyte puncture for IVF attempt, with a history of unilateral tubal surgery: salpingectomy for ectopic pregnancy. We conducted a case-control study, comparing the sonographic parameters of the surgery ovary (case) to those of the safe ovary (control) during the first IVF attempt after salpingectomy. The ovarian sonographic response was evaluated according to the follicular antral count on day 3 and the sonographic follicular count on trigger day. Results 55 patients were included. There was no significant difference in the number of recruited follicles on the operated side versus control side (p = 0.85 for >14 mm follicles, p = 0,46 for 10 to 14 mm, p = 0,52 for total amount of recruited follicles). There was no significant difference for the follicular antral count neither (p = 0.79). Discussion In our population, there was no significant difference in the sonographic ovarian response to IVF stimulation between the ovary on the operated side and the control ovary among patients treated by unilateral salpingectomy for ectopic pregnancy.

Keywords: IVF; Fertility; salpingectomy; Ovarian response

Domains: Gynecology and obstetrics

Camille Gay, Jeanne Perrin, Blandine Courbiere, Florence Bretelle, Aubert Agostini. Impact of salpingectomy for ectopic pregnancy on the ovarian response during IVF stimulation. Journal of Gynecology Obstetrics and Human Reproduction, 2019, 48 (9), pp.727-730. ⟨10.1016/j.jogoh.2019.05.009⟩. ⟨hal-02262495⟩