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Characteristics of Systemic Sclerosis patients with positive anti-Th/To antibodies: About 6 patients and literature review

Abstract : Among the antibodies described in Systemic Sclerosis (SSc), anti-Th/To antibodies (anti-Th/To) are rare and have been poorly studied. Thus, little is known about the profile of anti-Th/To positive patients. From our local Biobank (Marseille, France), we retrospectively selected data for 6 patients positive for anti-Th/To with an Immunodot assay. All of them suffered from SSc, sharing clinical and biological common features such as a limited cutaneous form of SSc, a decreased lung diffusing capacity and a speckled nuclear nucleolar immunofluorescence pattern of antinuclear antibodies screening on HEp-2 cells. In order to further characterize patients positive for anti-Th/To, we performed a thorough literature review. From 402 studied patients positive for anti-Th/To, we confirmed that these antibodies are associated with the limited cutaneous form of the disease (88% of the patients), and with an SSc related-pulmonary involvement (50%). The review analysis pointed out the rarity of the anti-Th/To with an estimated mean frequency of 3.4% of all SSc patients worldwide, their usual exclusivity with respect to the specific antibodies of scleroderma, and their high specificity (around 98%) for the diagnosis of SSc.
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Contributor : Isabelle Combe <>
Submitted on : Wednesday, March 10, 2021 - 11:44:44 AM
Last modification on : Wednesday, March 10, 2021 - 12:03:34 PM

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R. Muller, A. Benyamine, D. Bertin, J.-R. Harlé, G. Kaplanski, et al.. Characteristics of Systemic Sclerosis patients with positive anti-Th/To antibodies: About 6 patients and literature review. La Revue De Médecine Interne, Elsevier, 2020, ⟨10.1016/j.revmed.2019.12.020⟩. ⟨hal-02504556⟩

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