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Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.

Abstract : In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. It is of paramount importance to define when a treated patient can be considered as no longer contagious. Correlation between successful isolation of virus in cell culture and Ct value of quantitative RT-PCR targeting E gene suggests that patients with Ct above 33-34 using our RT-PCR system are not contagious and thus can be discharged from hospital care or strict confinement for non-hospitalized patients.
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https://hal-amu.archives-ouvertes.fr/hal-02564271
Contributor : Isabelle Combe <>
Submitted on : Tuesday, May 5, 2020 - 6:10:56 PM
Last modification on : Wednesday, May 6, 2020 - 1:41:51 AM

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Bernard La Scola, Marion Le Bideau, Julien Andreani, van Thuan Hoang, Clio Grimaldier, et al.. Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.. European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2020, ⟨10.1007/s10096-020-03913-9⟩. ⟨hal-02564271⟩

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