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Antifungal susceptibility testing practices in mycology laboratories in France, 2018

A.-P. Bellanger 1 F. Persat 2 F. Foulet 3 C. Bonnal 4 I. Accoceberry 5 C. Angebault 6 A. Angoulvant 7, 8 O. Augereau 9 E. Bailly 10 F. Bert 11 J. Bonhomme 12 J.-P. Bouchara 13 M.-E. Bougnoux 14 P. Bourdeau 15 B. Bouteille 16 S. Brun 17 K. Brunet 18, 19 A.-M. Camin-Ravenne 20 S. Cassaing 21 T. Chouaki 22 M. Cornet 23 D. Costa 24 N. Desbois 25 J. Dorin 26 A. Fekkar 27 A. Fiacre 28 E. Fréalle 29 J.-P. Gangneux 30 J. Guillot J. Guitard 31 L. Hasseine 32 A. Huguenin 33 L. Lachaud 34 S. Larréché 35 R.-A. Lavergne 36 S. Le Gal 13 Y. Le Govic 13 V. Letscher-Bru 37 M. Machouart 26 E. Mazars 38 C. Nourrisson 39 A. Paugam 40 S. Ranque 41 V. Risco-Castillo 6 M. Sasso 42 M. Sautour 43 B. Sendid 44, 28 Y. Senghor 31 F. Botterel 45 Eric Dannaoui 46, *
* Corresponding author
28 Service de Parasitologie-Mycologie [CHRU LIlle]
Institut de Microbiologie [CHRU Lille]
Abstract : A survey of mycology laboratories for antifungal susceptibility testing (AFST) was undertaken in France in 2018, to better understand the difference in practices between the participating centers and to identify the difficulties they may encounter as well as eventual gaps with published standards and guidelines. The survey captured information from 45 mycology laboratories in France on how they perform AFST (number of strains tested, preferred method, technical and quality aspects, interpretation of the MIC values, reading and interpretation difficulties). Results indicated that 86% of respondents used Etest as AFST method, with a combination of one to seven antifungal agents tested. Most of the participating laboratories used similar technical parameters to perform their AFST method and a large majority used, as recommended, internal and external quality assessments. Almost all the participating mycology laboratories (98%) reported difficulties to interpret the MIC values, especially when no clinical breakpoints are available. The survey highlighted that the current AFST practices in France need homogenization, particularly for MIC reading and interpretation.
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A.-P. Bellanger, F. Persat, F. Foulet, C. Bonnal, I. Accoceberry, et al.. Antifungal susceptibility testing practices in mycology laboratories in France, 2018. Journal de Mycologie Médicale, Elsevier Masson, 2020, 30 (2), pp.100970. ⟨10.1016/j.mycmed.2020.100970⟩. ⟨hal-02566987⟩

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