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Antifungal susceptibility testing practices in mycology laboratories in France, 2018

A.-P. Bellanger 1 F. Persat 2 F. Foulet 3 C. Bonnal 4 I. Accoceberry 5 C. Angebault 6 A. Angoulvant 7, 8 O. Augereau 9 E. Bailly 10 F. Bert 11 J. Bonhomme 12 J.-P. Bouchara 13, 14 M.-E. Bougnoux 15 P. Bourdeau 16 B. Bouteille 17 S. Brun 18 K. Brunet 19, 20 A.-M. Camin-Ravenne 21 S. Cassaing 22 T. Chouaki 23 M. Cornet 24 D. Costa 25 N. Desbois 26 J. Dorin 27 A. Fekkar 28 A. Fiacre 29 E. Fréalle 30 J.-P. Gangneux 31 J. Guillot J. Guitard 32 L. Hasseine 33 A. Huguenin 34, 35 L. Lachaud 36 S. Larréché 37 R.-A. Lavergne 38 S. Le Gal 13, 39 Y. Le Govic 13 V. Letscher-Bru 40 M. Machouart 27 E. Mazars 41 C. Nourrisson 42 A. Paugam 43 S. Ranque 44 V. Risco-Castillo 6 M. Sasso 45 M. Sautour 46 B. Sendid 29, 47 Y. Senghor 32 F. Botterel 48 Eric Dannaoui 49, *
* Corresponding author
29 Service de Parasitologie-Mycologie [CHRU LIlle]
Institut de Microbiologie [CHRU Lille]
Abstract : A survey of mycology laboratories for antifungal susceptibility testing (AFST) was undertaken in France in 2018, to better understand the difference in practices between the participating centers and to identify the difficulties they may encounter as well as eventual gaps with published standards and guidelines. The survey captured information from 45 mycology laboratories in France on how they perform AFST (number of strains tested, preferred method, technical and quality aspects, interpretation of the MIC values, reading and interpretation difficulties). Results indicated that 86% of respondents used Etest as AFST method, with a combination of one to seven antifungal agents tested. Most of the participating laboratories used similar technical parameters to perform their AFST method and a large majority used, as recommended, internal and external quality assessments. Almost all the participating mycology laboratories (98%) reported difficulties to interpret the MIC values, especially when no clinical breakpoints are available. The survey highlighted that the current AFST practices in France need homogenization, particularly for MIC reading and interpretation.
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A.-P. Bellanger, F. Persat, F. Foulet, C. Bonnal, I. Accoceberry, et al.. Antifungal susceptibility testing practices in mycology laboratories in France, 2018. Journal of Medical Mycology / Journal de Mycologie Médicale, Elsevier Masson, 2020, 30 (2), pp.100970. ⟨10.1016/j.mycmed.2020.100970⟩. ⟨hal-02566987⟩

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