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fosM , a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota

Abstract : ABSTRACT Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined in vitro/in silico approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Escherichia coli strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named fosM .
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https://hal-amu.archives-ouvertes.fr/hal-03216141
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Submitted on : Monday, May 3, 2021 - 5:51:01 PM
Last modification on : Friday, April 1, 2022 - 3:44:10 AM

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Sami Khabthani, Mouna Hamel, Sophie Alexandra Baron, Seydina Diene, Jean-Marc Rolain, et al.. fosM , a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2021, 65 (2), ⟨10.1128/AAC.01712-20⟩. ⟨hal-03216141⟩

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