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Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition

Abstract : Abstract Gut microbial dysbiosis has been shown to be an instrumental factor in severe acute malnutrition (SAM) and particularly, the absence of Methanobrevibacter smithii, a key player in energy harvest. Nevertheless, it remains unknown whether this absence reflects an immaturity or a loss of the microbiota. In order to assess that, we performed a case–control study in Mali using a propensity score weighting approach. The presence of M. smithii was tested using quantitative PCR on faeces collected from SAM children at inclusion and at discharge when possible or at day 15 for controls. M. smithii was highly significantly associated with the absence of SAM, detected in 40.9% controls but only in 4.2% cases (p < 0.0001). The predictive positive value for detection of M. smithii gradually increased with age in controls while decreasing in cases. Among children providing two samples with a negative first sample, no SAM children became positive, while this proportion was 2/4 in controls (p = 0.0015). This data suggests that gut dysbiosis in SAM is not an immaturity but rather features a loss of M. smithii . The addition of M. smithii as a probiotic may thus represent an important addition to therapeutic approaches to restore gut symbiosis.
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Submitted on : Thursday, June 3, 2021 - 10:01:23 AM
Last modification on : Friday, February 4, 2022 - 3:26:22 AM
Long-term archiving on: : Saturday, September 4, 2021 - 6:14:00 PM


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Aminata Camara, Salimata Konate, Maryam Tidjani Alou, Aly Kodio, Amadou Hamidou Togo, et al.. Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition. Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-84641-8⟩. ⟨hal-03243126⟩



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