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2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one

Abstract : As part of our ongoing scaffold hopping work on antimalarial 2-aminothieno[3,2-d]pyrimidin-4-one scaffold, we explored the dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one as a potential new antimalarial series. Using conditions found in the literature, we obtained 2-cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one with 93% yield through a simple treatment. It was then characterized by NMR (1H and 13C) and HRMS. Given the structure of this molecule, its aqueous stability was assessed to determine its suitability for biological tests. To our knowledge, this is the first dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one described
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https://hal-amu.archives-ouvertes.fr/hal-03246463
Contributor : Nicolas Primas <>
Submitted on : Wednesday, June 2, 2021 - 1:31:52 PM
Last modification on : Thursday, June 3, 2021 - 3:38:07 AM

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Romain Mustière, Patrice Vanelle, Nicolas Primas. 2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one. Molbank, MDPI, 2021, 2021 (2), ⟨10.3390/m1221⟩. ⟨hal-03246463⟩

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