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Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2021

DNAse-dependent, NET-independent pathway of thrombus formation in vivo

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Abstract

Significance Thrombosis constitutes a major contributor to the global disease burden. Recently, the contribution of neutrophils and neutrophil extracellular traps in thrombosis has been intensively documented. DNAse-I by its ability to cleave DNA has been proposed as an efficient antithrombotic drug. In this paper, we showed that DNase-I inhibits the formation of a platelet thrombus and the generation of fibrin independent of its enzymatic activity on DNA. We proposed that DNase-I hydrolyzes adenosine triphosphate and adenosine diphosphate (two important platelet and neutrophil agonists) into adenosine, an antagonist of platelet and neutrophil.

Dates and versions

hal-03647480 , version 1 (20-04-2022)

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Estelle Carminita, Lydie Crescence, Nicolas Brouilly, Alexandre Altié, Laurence Panicot-Dubois, et al.. DNAse-dependent, NET-independent pathway of thrombus formation in vivo. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (28), pp.e2100561118. ⟨10.1073/pnas.2100561118⟩. ⟨hal-03647480⟩
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