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Spike and neutralizing antibodies response to COVID-19 vaccination in haemodialysis patients

Abstract : Abstract Background Humoral response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines needs to be evaluated in the fragile population of patients on maintenance haemodialysis (HD). Methods We analysed the antibody response to the spike (S) antigen of SARS-CoV-2 before and after each dose of the messenger RNA (mRNA) Comirnaty vaccine (BNT162b2; BioNTech & Pfizer) in patients from a single dialysis centre and detected the presence of neutralizing antibodies (Nabs). Results Among the 90 vaccinated HD patients (mean age 69 years, 61% male), 19 (21%) had a history of SARS-CoV-2 infection. A seroconversion with anti-S immunoglobulin G antibodies (Sabs) was documented in 20% of patients after the first dose (early responders) and in 77% after the second dose, while 23% were non-responders. Cardiac disease, cirrhosis and gamma globulin levels were independently predictive of the absence of seroconversion. Nabs were detected in 15.4% of early responders after the first dose and in 84.6% of early responders and 57.9% of late responders after the second dose. Sab titres after the second dose were higher in patients with Nab than without Nab {598 [interquartile range (IQR) 246–882]) versus 134 [IQR 61–390]; P < 0.0001}. All patients with a history of SARS-CoV-2 infection developed both Sabs and Nabs and their titres for Sabs and Nabs were higher than in late responders. Conclusions Most HD patients develop a substantial humoral response against SARS-CoV2, with Nabs, following the mRNA vaccine. Whether this immunity persists over time and is able to efficiently protect patients from coronavirus disease 2019 remains to be determined.
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https://hal-amu.archives-ouvertes.fr/hal-03662398
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Submitted on : Monday, May 9, 2022 - 12:13:50 PM
Last modification on : Wednesday, October 12, 2022 - 4:03:42 PM

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Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

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Matthieu Giot, Toscane Fourié, Guillaume Lano, Paola Mariela Saba Villarroel, Xavier De Lamballeri, et al.. Spike and neutralizing antibodies response to COVID-19 vaccination in haemodialysis patients. Clinical Kidney Journal, 2021, 14 (10), pp.2239-2245. ⟨10.1093/ckj/sfab128⟩. ⟨hal-03662398⟩

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