Immunomodulation by Mosquito Salivary Protein AgSAP Contributes to Early Host Infection by Plasmodium

Gunjan Arora (1) , Andaleeb Sajid , Yu-Min Chuang , Yuemei Dong (2) , Akash Gupta , Kristen Gambardella , Kathleen Deponte , Lionel Almeras (3, 4, 5) , George Dimopolous (2) , Erol Fikrig (1)

1 Yale University [New Haven]
2 Johns Hopkins University School of Medicine [Baltimore]
3 VITROME - Vecteurs - Infections tropicales et méditerranéennes
4 IRBA - Institut de Recherche Biomédicale des Armées [Antenne Marseille]
5 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection

Malaria is a vector-borne disease caused by Plasmodium sporozoites. When an anopheline mosquito bites its host, it releases Plasmodium sporozoites as well as saliva components.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system; Life Sciences [q-bio]; Human health and pathology; Emerging diseases; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Gunjan Arora, Andaleeb Sajid, Yu-Min Chuang, Yuemei Dong, Akash Gupta, et al.. Immunomodulation by Mosquito Salivary Protein AgSAP Contributes to Early Host Infection by Plasmodium. mBio, 2021, 12 (6), ⟨10.1128/mBio.03091-21⟩. ⟨hal-03663570⟩