Advancing natural killer therapies against cancer

Emilie Narni-Mancinelli (1) , Eric Vivier (1, 2, 3)

1 CIML - Centre d'Immunologie de Marseille - Luminy
2 Innate Pharma
3 TIMONE - Hôpital de la Timone [CHU - APHM]

Natural killer (NK)-based therapies against cancer are emerging, but the understanding of NK cell functions needs to be completed to optimize these treatments. In this issue, Pan et al. (2022) show that pro-apoptotic molecules, such as BH3-mimetics, synergize with NK cells to induce mitochondria-driven apoptosis in tumor cells, thereby enhancing the efficacy of NK cell therapies.

Domaines: Sciences du Vivant [q-bio]

Emilie Narni-Mancinelli, Eric Vivier. Advancing natural killer therapies against cancer. Cell, 2022, 185 (9), pp.1451-1454. ⟨10.1016/j.cell.2022.04.006⟩. ⟨hal-03960073⟩